Related Experiment Video
Updated: Jun 8, 2026

Implementing Patch Clamp and Live Fluorescence Microscopy to Monitor Functional Properties of Freshly Isolated PKD Epithelium
Published on: September 1, 2015
Elevated salivary potassium in paediatric CKD patients, a novel excretion pathway
Esti Davidovich1, Miriam Davidovits, Benny Peretz
1Department of Pediatric Dentistry Hebrew University-Hadassah Faculty of Dental Medicine, Jerusalem, Israel.
Background:
Hyperkalaemia is one of the complications of chronic renal failure. Gastrointestinal excretion and cellular uptake are two adaptive mechanisms for extra-renal potassium (K) disposal in these patients. The salivary glands' secretion system can actively excrete K into the oral cavity.
Methods:
We examined salivary K levels in four groups of paediatric chronic kidney disease (CKD) patients: 25 pre-dialytic (PreD) patients, 18 patients on maintenance dialysis (D), and 31 transplanted patients with a functioning graft (T), compared with 32 healthy children (C).
Results:
Salivary K levels were significantly higher in the D and PreD groups than the C group (P = 0.03 and P = 0.0004, respectively). Interestingly, a significant negative correlation was found between glomerular filtration rate and salivary K in PreD and T patients.
Conclusions:
We suggest an extension of the gastrointestinal adaptive K pathway via salivary gland secretion in patients suffering from hyperkalaemia.
More Related Videos
Related Concept Videos
Antihypertensive Drugs: Potassium-Sparing Diuretics
Pharmacokinetics in Pediatric Patients: Drug Excretion
Renal Drug Excretion: Tubular Secretion
Renal Drug Excretion: Effect of Urine pH, Flow Rate, and Drug pKa
The pKa of a drug,...
Renal Drug Excretion: Tubular Reabsorption
Physiology of the Genitourinary System II: Tubular Reabsorption and Secretion

