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Serotype distribution and susceptibility of Streptococcus pneumoniae isolates from pleural fluid in Spain from 1997

A Fenoll1, L Aguilar, M D Vicioso

  • 1Spanish Reference Pneumococcal Laboratory, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain.

Antimicrobial Agents and Chemotherapy
|October 6, 2010
PubMed

Insights

Trends in Streptococcus pneumoniae pleural infections show decreasing penicillin resistance and 7-valent pneumococcal conjugate vaccine (PCV-7) serotypes. However, serotypes 1 and 19A are increasing, particularly in children.

Area of Science:

  • Microbiology
  • Epidemiology
  • Vaccinology

Background:

  • Streptococcus pneumoniae is a leading cause of bacterial pneumonia.
  • Understanding serotype trends and antimicrobial susceptibility is crucial for effective prevention and treatment.

Purpose of the Study:

  • To analyze trends in serotype incidence and antimicrobial susceptibility of S. pneumoniae pleural isolates in Spain from 1997 to 2008.
  • To evaluate the impact of the 7-valent pneumococcal conjugate vaccine (PCV-7) on serotype distribution.

Main Methods:

  • Retrospective analysis of 831 S. pneumoniae pleural isolates collected between 1997 and 2008.
  • Statistical analysis to determine trends in serotype incidence and penicillin nonsusceptibility.

Main Results:

  • Decreasing trends observed in penicillin nonsusceptibility rates and the incidence of PCV-7 serotypes.
  • Significant increasing trends noted for serotypes 1 and 19A (P < 0.001).
  • In 2008, serotypes 19A, 1, and 3 accounted for 85% of pediatric isolates, with 82.4% of 19A isolates showing penicillin nonsusceptibility.

Conclusions:

  • The emergence of non-susceptible serotypes 1 and 19A necessitates updated vaccination strategies.
  • Inclusion of these prevalent and resistant serotypes in new vaccines is recommended for broader coverage.

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