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Related Experiment Video

Updated: Jun 8, 2026

Microfluidic Co-Culture Models for Dissecting the Immune Response in in vitro Tumor Microenvironments

Microfluidic Co-Culture Models for Dissecting the Immune Response in in vitro Tumor Microenvironments

Published on: April 30, 2021

Comparative effectiveness and personalized medicine: evolving together or apart?

Robert Epstein¹, J Russell Teagarden

¹Medco ResearchInstitute, Medco Health Solutions, Franklin Lakes, New Jersey, USA. Robert_Epstein@medco.com

Health Affairs (Project Hope)

|October 6, 2010

Summary

Comparative effectiveness research (CER) and personalized medicine (PM) seem opposed but can work together. CER identifies patient subgroups benefiting most from specific treatments, improving outcomes and costs.

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Last Updated: Jun 8, 2026

Microfluidic Co-Culture Models for Dissecting the Immune Response in in vitro Tumor Microenvironments

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Published on: April 30, 2021

Integration of Wet and Dry Bench Processes Optimizes Targeted Next-generation Sequencing of Low-quality and Low-quantity Tumor Biopsies

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Published on: April 11, 2016

Area of Science:

Health services research
Genomics
Medical informatics

Background:

Comparative effectiveness research (CER) and personalized medicine (PM) are often viewed as conflicting approaches.
CER focuses on general patient populations, while PM targets specific patient subsets based on individual characteristics like genetics.

Purpose of the Study:

To explore the synergistic relationship between CER and PM.
To demonstrate how CER can inform the application of PM in healthcare.

Main Methods:

Analysis of existing CER methodologies and their application to heterogeneous patient populations.
Review of how identifying subpopulations within CER studies can align with PM principles.

Main Results:

CER, by enrolling diverse patient groups, can reveal specific subpopulations that respond best to particular therapies.
This uncovers the potential for CER to guide the implementation of PM strategies.

Conclusions:

CER and PM are complementary, not contradictory.
CER can identify the optimal role for PM in enhancing healthcare outcomes and managing costs effectively.