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Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...

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Related Experiment Video

Updated: Jun 8, 2026

A 3D Organotypic Melanoma Spheroid Skin Model
08:49

A 3D Organotypic Melanoma Spheroid Skin Model

Published on: May 18, 2018

Disseminated malignant melanoma.

K K Verma1, P D'Souza, C S Sirka

  • 1Department of Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi-110029, India.

Indian Journal of Dermatology, Venereology and Leprology
|October 6, 2010
PubMed
Summary
This summary is machine-generated.

A young man presented with skin lesions and neurological symptoms, diagnosed as malignant melanoma. Despite symptomatic treatment, the disseminated cancer led to his death within four months.

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Area of Science:

  • Dermatology
  • Oncology
  • Neurology

Background:

  • Malignant melanoma can present with diverse clinical manifestations.
  • Disseminated melanoma poses a significant diagnostic and therapeutic challenge.

Purpose of the Study:

  • To report a rare case of disseminated malignant melanoma presenting with neurological symptoms.
  • To highlight the importance of early diagnosis and comprehensive evaluation in suspected melanoma cases.

Main Methods:

  • Clinical presentation of a 25-year-old male with nodular skin lesions and facial palsy.
  • Skin biopsy with histopathological examination.
  • Immunohistochemical staining using Fontana Masson and S-100 protein.

Main Results:

  • Histopathology confirmed malignant melanoma.
  • S-100 protein staining was positive, supporting melanoma diagnosis.
  • The patient had disseminated malignant melanoma with neurological involvement.

Conclusions:

  • Disseminated malignant melanoma can manifest with unusual symptoms like facial palsy.
  • Prompt diagnosis and symptomatic management are crucial.
  • The aggressive nature of disseminated melanoma can lead to rapid deterioration.