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Related Concept Videos

Cellular Injury IV: Necrosis01:16

Cellular Injury IV: Necrosis

Necrosis is a form of irreversible cell death caused by severe injury such as ischemia, toxins, or trauma. Unlike programmed cell death, it is an uncontrolled, pathological process that typically provokes inflammation in surrounding tissues.Pathophysiologic ChangesNecrosis begins when cells sustain critical damage, leading to swelling of organelles, particularly mitochondria, and rapid ATP depletion. As energy levels decline, membrane ion pumps fail, leading to calcium influx and eventually,...
Necrosis01:16

Necrosis

Necrosis is considered as an “accidental” or unexpected form of cell death that ends in cell lysis. The first noticeable mention of “necrosis” was in 1859 when Rudolf Virchow used this term to describe advanced tissue breakdown in his compilation titled “Cell Pathology”.
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become anucleated and die, but their...
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Appendicitis

Appendicitis is an acute inflammatory condition of the vermiform appendix, most commonly caused by obstruction of its lumen. The appendix is a narrow, blind-ended pouch that extends from the cecum, making it particularly prone to obstruction. Causes include fecaliths, lymphoid hyperplasia (often after viral infections), parasites, tumors, or foreign bodies. This obstruction initiates a cascade of pathological changes.Luminal Obstruction and Early InflammationAfter obstruction, normal mucosal...
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Related Experiment Videos

Necrotising fasciitis.

B D Sathyanarayana1, B Leelavathy

  • 1From the Department of Skin and STD, Bangalore Medical College, Bangalore, India, .

Indian Journal of Dermatology, Venereology and Leprology
|October 6, 2010
PubMed
Summary
This summary is machine-generated.

Necrotising fasciitis, a severe infection, can lead to permanent flexion deformities if diagnosis and treatment are delayed. Prompt medical intervention is crucial to prevent such debilitating complications.

Related Experiment Videos

Area of Science:

  • Infectious Diseases
  • Surgical Pathology
  • Orthopedic Complications

Background:

  • Necrotising fasciitis is a rapidly progressive bacterial infection of the soft tissues.
  • Delays in diagnosis and treatment are associated with increased morbidity and mortality.
  • Soft tissue necrosis can lead to significant functional impairment.

Purpose of the Study:

  • To report a case of necrotising fasciitis with a delayed diagnosis.
  • To highlight the potential for contracture and flexion deformity as a sequela.
  • To emphasize the importance of timely intervention in managing this critical condition.

Main Methods:

  • Case report detailing the clinical presentation, diagnostic process, and treatment of necrotising fasciitis.
  • Review of the patient's progression from initial infection to the development of contractures.
  • Documentation of the resulting flexion deformity.

Main Results:

  • The patient presented with necrotising fasciitis.
  • Delayed diagnosis and treatment resulted in the development of contractures.
  • A significant flexion deformity was observed as a consequence of the infection and subsequent tissue changes.

Conclusions:

  • Necrotising fasciitis, if not treated promptly, can lead to severe complications such as contractures and functional deformities.
  • Early recognition and aggressive management are paramount to prevent long-term sequelae.
  • This case underscores the critical need for prompt surgical and medical intervention in suspected necrotising fasciitis.