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Related Concept Videos

Papillary Dermis01:11

Papillary Dermis

Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen and...
Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Reticular Dermis01:15

Reticular Dermis

The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
Reticular Layer
Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...
Accessory Structures of the Skin: Sebaceous Glands01:21

Accessory Structures of the Skin: Sebaceous Glands

A sebaceous gland is a type of oil gland found almost all over the skin ( except palms and soles) and helps lubricate and waterproof the skin and hair. Most sebaceous glands are associated with hair follicles. They generate and excrete sebum, a mixture of lipids, onto the skin surface, thereby naturally lubricating the dry and dead layer of keratinized cells of the stratum corneum, keeping it pliable.
These glands that produce the oils on the skin and hair are holocrine glands. The mature...
Accessory Structures of the Skin: Hair Growth and Types01:20

Accessory Structures of the Skin: Hair Growth and Types

Hair growth begins with the production of keratinocytes by the basal cells of the hair bulb. As new cells are deposited at the hair bulb, the hair shaft is pushed through the follicle toward the surface. Keratinization is completed as the cells are pushed to the skin surface to form the shaft of hair that is externally visible. The external hair is completely dead and composed entirely of keratin. Hair can be cut or shaven without damaging the hair structure because the cut is superficial. Most...
Accessory Structures of the Skin: Hair and Hair Follicles01:16

Accessory Structures of the Skin: Hair and Hair Follicles

Hair and hair follicles are integral components of the integumentary system. Hair is a filamentous structure composed mainly of a protein called keratin. It is found on the surface of the skin throughout the body, except for areas such as the palms of the hands and soles of the feet.
Hair is a keratinous filament growing out of the epidermis. It is primarily made of dead, keratinized cells. Hair strands originate at the epidermal penetration called the hair follicle. The hair shaft is the part...

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Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia
06:15

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

Spitz nevus.

H Mohan1, R Chopra, K Bhardwaj

  • 1From the Department of Pathology, Government Medical College, Chandigarh- 160 047, India, .

Indian Journal of Dermatology, Venereology and Leprology
|October 6, 2010
PubMed
Summary
This summary is machine-generated.

This case report highlights the diagnostic challenges of Spitz nevi, particularly those with epithelioid cells, in distinguishing them from malignant melanoma. Recognizing these uncommon presentations is crucial for accurate diagnosis.

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Area of Science:

  • Dermatology
  • Pathology
  • Oncology

Background:

  • Spitz nevi are benign skin tumors that can clinically and histologically mimic malignant melanoma.
  • Distinguishing Spitz nevi from melanoma is critical for appropriate patient management and to avoid overtreatment.
  • Epithelioid Spitz nevi represent a less common subtype, posing diagnostic difficulties.

Purpose of the Study:

  • To present a case of epithelioid Spitz nevus.
  • To emphasize the diagnostic challenges in differentiating this entity from malignant melanoma.
  • To review the key features aiding in the distinction between Spitz nevus and melanoma.

Main Methods:

  • Histopathological examination of a skin biopsy.
  • Clinical correlation of the lesion's presentation.
  • Review of relevant literature on Spitz nevi and melanoma.

Main Results:

  • The presented case demonstrated features of Spitz nevus with a predominantly epithelioid cell component.
  • Histopathological analysis revealed specific cellular and architectural characteristics.
  • Differential diagnosis with malignant melanoma was considered based on morphological features.

Conclusions:

  • Epithelioid Spitz nevus is an uncommon variant that requires careful histopathological evaluation.
  • Accurate differentiation from malignant melanoma is essential and relies on a combination of clinical and pathological findings.
  • This case underscores the importance of recognizing challenging presentations of Spitz nevi in dermatopathology.