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Preparation of Single-cell Suspensions for Cytofluorimetric Analysis from Different Mouse Skin Regions
Published on: April 20, 2016
Chemokines in the skin.
1Department of Dermatology, Himalayan Institute of Medical Sciences, Jolly Grant, Dehradun, U.P, India.
Indian Journal of Dermatology, Venereology and Leprology
|October 6, 2010
Summary
Chemokines, involved in specific cell targeting and chronic skin diseases, interact with G-protein-coupled receptors. These chemokine receptors are now key targets for anti-HIV therapies due to their role in HIV-1 infection.
Area of Science:
- Immunology
- Cell Biology
- Virology
Background:
- Focus has shifted from pleiotropic cytokines to target cell-selective chemokines.
- Chemokines are implicated in the pathogenesis of diseases with specific cellular infiltrates, including chronic skin diseases.
- Chemokines are classified into CXC, CC, and C subfamilies based on structural characteristics.
Purpose of the Study:
- To explore the interaction between chemokines and their cloned receptors.
- To highlight the emerging role of chemokine receptors as targets for anti-HIV therapy.
- To identify specific chemokine receptors implicated as HIV-1 coreceptors.
Main Methods:
- Cloning of chemokine receptors, which are members of the G-protein-coupled receptor family.
- Investigating the interaction between chemokines and their cloned receptors.
- Establishing the connection between chemokines and HIV-1 infection.
Main Results:
- Seven CC chemokine receptors and CXC chemokine receptors have been cloned.
- Chemokine receptors have emerged as crucial targets for anti-HIV therapy.
- Specific receptors like CXCR4, CCR1, CCR2b, CCR3, and CCR5 are implicated as HIV-1 coreceptors.
Conclusions:
- Chemokine receptors play a significant role in HIV-1 infection.
- Targeting chemokine receptors offers a promising strategy for anti-HIV therapy.
- Further research into chemokine-receptor interactions is vital for understanding disease pathogenesis and developing novel treatments.
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