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Related Concept Videos

Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Cancers Originate from Somatic Mutations in a Single Cell02:21

Cancers Originate from Somatic Mutations in a Single Cell

Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
Cancers Originate from Somatic Mutations in a Single Cell02:21

Cancers Originate from Somatic Mutations in a Single Cell

Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...

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Comparative Lesions Analysis Through a Targeted Sequencing Approach
08:16

Comparative Lesions Analysis Through a Targeted Sequencing Approach

Published on: November 5, 2019

Monomorphic cutaneous metastases with different primaries.

R Muthukumaran1, G Nirmaladevi, V R Janaki

  • 1Department of Dermatology, Chennai Medical College, Chennai-600 003, India.

Indian Journal of Dermatology, Venereology and Leprology
|October 6, 2010
PubMed
Summary
This summary is machine-generated.

This study details telangiectatic cutaneous metastases, a rare cancer spread, in a female breast cancer patient and a male laryngeal cancer patient. It highlights the clinical and histopathological characteristics of these secondary skin tumors.

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Area of Science:

  • Dermatology
  • Oncology
  • Pathology

Background:

  • Secondary cutaneous metastases represent cancer spread to the skin from a primary tumor elsewhere.
  • Telangiectatic metastases are a specific subtype characterized by prominent blood vessels.
  • Such metastases can arise from various primary malignancies.

Purpose of the Study:

  • To describe the clinical and histopathological features of telangiectatic secondary cutaneous metastases.
  • To present cases of telangiectatic metastases originating from breast adenocarcinoma and laryngeal squamous cell carcinoma.

Main Methods:

  • Case report analysis.
  • Clinical examination of skin lesions.
  • Histopathological examination of biopsy specimens.
  • Review of primary tumor characteristics.

Main Results:

  • Detailed description of the clinical presentation of telangiectatic cutaneous metastases in two patients.
  • Histopathological findings consistent with metastatic adenocarcinoma (breast primary) and squamous cell carcinoma (larynx primary).
  • Correlation between the morphology of skin lesions and the underlying primary cancer type.

Conclusions:

  • Telangiectatic cutaneous metastases can occur with diverse primary malignancies, including breast and laryngeal cancers.
  • Clinical and histopathological evaluation is crucial for diagnosing these rare metastatic patterns.
  • Understanding these presentations aids in patient management and prognosis.