Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Drugs Acting on Autonomic Ganglia: Stimulants

Drugs Acting on Autonomic Ganglia: Stimulants

Ganglionic stimulants activate NM nicotinic receptors in autonomic ganglia, falling into two categories: nicotine mimetics [e.g., lobeline, dimethylpiperazine, tetramethylammonium] and muscarinic receptor agonists [e.g., muscarine, methacholine]. The first category's action is rapid and blocked by nicotinic receptor antagonists, while the second category's action is delayed and blocked by atropine-like agents. Nicotine, an alkaloid, affects the heart rate by stimulating sympathetic or...

CNS Depressants: Alcohol and Nicotine

CNS Depressants: Alcohol and Nicotine

Ethanol, a clear colorless alcohol, has been consumed by humans for millennia, but its effects on the body are far from benign. At lower doses, it induces decreased inhibitions and loquaciousness, leading to its social appeal. However, it can cause severe consequences at higher doses, such as coma and respiratory depression, due to its zero-order elimination kinetics. Chronic ethanol abuse wreaks havoc on multiple organ systems, particularly the CNS and the liver. Abrupt cessation of ethanol...

Cholinergic Receptors: Nicotinic

Cholinergic Receptors: Nicotinic

Nicotinic receptors are ligand-gated ion channels that are activated by acetylcholine and nicotine. Upon activation, they cause a rapid increase in the permeability of cells to K+, Na+, and Ca2+, followed by depolarization and excitation. They are in the autonomic ganglia, skeletal neuromuscular junction, CNS, and adrenal medulla.
There are two types of nicotinic receptors: neuromuscular (NM/NM/N1) and neuronal (NN/NN/N2). The two families differ based on their location and selectivity to...

The Oral Microbiota

The Oral Microbiota

The oral microbiome includes a complex ecosystem comprising over 700 microbial species, identified through genomic sequencing and culture-based analyses to date. This community includes a core microbiome, found universally among individuals, and a variable component influenced by environmental factors such as diet, lifestyle, and host genetics. Site-specific conditions, including oxygen gradients, pH levels, and nutrient availability, determine the spatial distribution of these microorganisms...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Indian Society of Periodontology Good Clinical Practice Recommendations for dental pain management and use of analgesics.

Journal of Indian Society of Periodontology·2026

Same author

Metagenomic insights into oral microbiota dynamics in diabetic and non-diabetic periodontal disease: a pilot study.

Frontiers in microbiology·2026

Same author

Balancing act: Orthodontic strategies in severe periodontitis - updating clinical practice with evidence-based insights.

Medicine·2026

Same author

Effect of Salivary Contamination on the Surface Integrity and Corrosion Resistance of Dental Implants.

Journal of pharmacy & bioallied sciences·2026

Same author

Chitosan-functionalized mesoporous silica nanoparticles co-loaded with chrysin and quercetin: a potent strategy against lung cancer cells.

Scientific reports·2026

Same author

Effects of Curing Distance and Time on the Microhardness of Posterior Composites: An Experimental Study.

Cureus·2025

Search research articles

Related Experiment Video

Updated: Jun 8, 2026

Murine Model of Advanced Periodontitis Induced by Nylon Ligature in the Second Upper Molar

Murine Model of Advanced Periodontitis Induced by Nylon Ligature in the Second Upper Molar

Published on: May 30, 2025

Nicotine and periodontal tissues.

Ranjan Malhotra¹, Anoop Kapoor, Vishakha Grover

¹Department of Periodontology and Oral Implantology, National Dental College & Hospital, Derabassi, Punjab, India.

Journal of Indian Society of Periodontology

|October 6, 2010

Summary

Tobacco use significantly worsens periodontal disease, leading to severe oral health issues like tooth loss. Nicotine, a key tobacco component, exacerbates these conditions, highlighting the need for tobacco cessation in dental therapy.

Keywords:

Nicotine smoking smoking cessation tobacco

More Related Videos

Spectral Confocal Imaging of Fluorescently tagged Nicotinic Receptors in Knock-in Mice with Chronic Nicotine Administration

Spectral Confocal Imaging of Fluorescently tagged Nicotinic Receptors in Knock-in Mice with Chronic Nicotine Administration

Published on: February 10, 2012

Related Experiment Videos

Last Updated: Jun 8, 2026

Murine Model of Advanced Periodontitis Induced by Nylon Ligature in the Second Upper Molar

Murine Model of Advanced Periodontitis Induced by Nylon Ligature in the Second Upper Molar

Published on: May 30, 2025

Spectral Confocal Imaging of Fluorescently tagged Nicotinic Receptors in Knock-in Mice with Chronic Nicotine Administration

Spectral Confocal Imaging of Fluorescently tagged Nicotinic Receptors in Knock-in Mice with Chronic Nicotine Administration

Published on: February 10, 2012

Area of Science:

Periodontology
Oral Health
Toxicology

Background:

Tobacco use is a major risk factor for periodontal disease development and progression.
It is associated with increased pocket depths, attachment loss, alveolar bone loss, and tooth loss.
Nicotine, the primary psychoactive component of tobacco, is implicated in exacerbating periodontal disease.

Purpose of the Study:

To review the mechanisms by which nicotine contributes to the exacerbation of periodontal disease.
To emphasize the importance of integrating tobacco cessation into periodontal therapy.

Main Methods:

Literature review of studies investigating the effects of tobacco and nicotine on periodontal tissues.
Analysis of the impact of nicotine on gingival blood flow, immune cell function, and connective tissue turnover.

Main Results:

Nicotine affects gingival blood flow, cytokine production, and immune cell function.
It also influences connective tissue turnover, contributing to periodontal tissue damage.
These mechanisms explain the detrimental effects of tobacco on periodontal health.

Conclusions:

Nicotine plays a significant role in the progression of periodontal disease.
Integrating tobacco cessation counseling into periodontal therapy is crucial for improving patient outcomes.
This approach benefits both oral and overall patient health.