Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Kidney Transplant I: Introduction

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...

Kidney Transplant II: Surgical Procedure

Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...

Kidney Transplant III: Nursing Management

Kidney Transplant III: Nursing Management

Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...

Bone Marrow Sampling and Transplants

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...

Tissue Transplantation

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Microbial Ecology and Nutritional Features in Liquid Sourdough Containing Hemp Flour Fermented by Lactic Acid Bacterial Strains.

Foods (Basel, Switzerland)·2025

Same author

Okra (<i>Abelmoschus esculentus</i> L.) Flour Integration in Wheat-Based Sourdough: Effect on Nutritional and Technological Quality of Bread.

Foods (Basel, Switzerland)·2024

Same author

Functional foods in Mediterranean diet: exploring the functional features of vegetable case-studies obtained also by biotechnological approaches.

Aging clinical and experimental research·2024

Same author

Potential Prebiotic Effect of Inulin-Enriched Pasta after In Vitro Gastrointestinal Digestion and Simulated Gut Fermentation.

Foods (Basel, Switzerland)·2024

Same author

Synecology of Lagoecia cuminoides L. in Italy and evaluation of functional compounds presence in its water or hydroalcoholic extracts.

Scientific reports·2023

Same author

Modeling of Growth and Organic Acid Kinetics and Evolution of the Protein Profile and Amino Acid Content during <i>Lactiplantibacillus plantarum</i> ITM21B Fermentation in Liquid Sourdough.

Foods (Basel, Switzerland)·2022

Search research articles

Related Experiment Video

Updated: Jun 8, 2026

Murine Bilateral Renal Lymphadenectomy

Murine Bilateral Renal Lymphadenectomy

Published on: December 30, 2025

[Kidney transplantation and lymphomas].

Silvio Sandrini¹, Francesca Valerio, Monica Insalaco

¹Cattedra e Divisione di Nefrologia, A.O. Spedali Civili ed Universita', Brescia, Italy. sandrini.silvio@libero.it

Giornale Italiano Di Nefrologia : Organo Ufficiale Della Societa Italiana Di Nefrologia

|October 6, 2010

Summary

Post-transplant lymphoproliferative disease (PTLD) is a serious cancer risk after kidney transplants, often linked to Epstein-Barr virus (EBV). Late-occurring PTLD is more common and harder to treat, with significant mortality risks.

More Related Videos

Murine Kidney Transplant Technique

Murine Kidney Transplant Technique

Published on: October 20, 2015

Related Experiment Videos

Last Updated: Jun 8, 2026

Murine Bilateral Renal Lymphadenectomy

Murine Bilateral Renal Lymphadenectomy

Published on: December 30, 2025

Murine Kidney Transplant Technique

Murine Kidney Transplant Technique

Published on: October 20, 2015

Area of Science:

Oncology
Transplantation Immunology
Virology

Context:

Post-transplant lymphoproliferative disease (PTLD) represents a significant oncological complication following kidney transplantation, accounting for 30% of non-skin cancers.
The incidence of PTLD increases over time, with late-onset PTLD being more frequent and aggressive than early-onset PTLD.
Epstein-Barr virus (EBV) infection and the use of antilymphocyte agents are identified as critical risk factors, particularly in EBV-negative patients.

Purpose:

To review the epidemiology, risk factors, diagnosis, and management of post-transplant lymphoproliferative disease (PTLD) after kidney transplantation.
To highlight the challenges associated with late-occurring PTLD and the limited efficacy of current therapeutic strategies.
To emphasize the importance of monitoring for EBV-associated PTLD, especially in pediatric recipients.

Summary:

Diffuse large B-cell lymphoma is the predominant histological subtype of PTLD.
While EBV-PCR monitoring aids early diagnosis in the first year post-transplant, effective prevention strategies for late PTLD remain elusive.
Treatment involves immunosuppression interruption, with Rituximab showing 50% efficacy; chemotherapy is reserved for refractory cases, carrying substantial infectious risks and a 50% mortality rate within 12 months.

Impact:

This review underscores the critical need for improved diagnostic and therapeutic strategies for late-occurring PTLD to reduce patient mortality.
Understanding the role of EBV and immunosuppression is crucial for risk stratification and potential preventative measures.
The findings highlight the significant morbidity and mortality associated with PTLD, emphasizing the importance of vigilant post-transplant surveillance.