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Related Concept Videos

Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of fluid...
Diabetic Nephropathy01:28

Diabetic Nephropathy

Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration occur due to afferent arteriolar...
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
Nephrons01:10

Nephrons

The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma happens...
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...

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Isolated microalbuminuria as the first clinical presentation of Fabry disease in an adult heterozygous female.

NDT plus·2015
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Calcium profiling in hemodiafiltration: a new way to reduce the calcium overload risk without compromising cardiovascular stability.

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[Parainfectious glomerulonephritis].

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The effect of on-line high-flux hemofiltration versus low-flux hemodialysis on mortality in chronic kidney failure: a small randomized controlled trial.

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A Case Report and Literature Review: Chlorhexidine-induced anaphylaxis in a hemodialysis patient.

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Related Experiment Video

Updated: Jun 8, 2026

Glomerular Outgrowth as an Ex Vivo Assay to Analyze Pathways Involved in Parietal Epithelial Cell Activation
06:39

Glomerular Outgrowth as an Ex Vivo Assay to Analyze Pathways Involved in Parietal Epithelial Cell Activation

Published on: August 19, 2020

[Solid tumors and paraneoplastic glomerulonephritis].

Leonardo Cagnoli1

  • 1U.O.C. di Nefrologia e Dialisi, Ospedale degli Infermi, Rimini, Italy. lcagnoli@auslrn.net

Giornale Italiano Di Nefrologia : Organo Ufficiale Della Societa Italiana Di Nefrologia
|October 6, 2010
PubMed
Summary
This summary is machine-generated.

Paraneoplastic glomerulonephritis, a rare kidney disease linked to cancer, often presents as membranous nephropathy. Early cancer screening and treatment are crucial, avoiding immunosuppression.

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Murine Bilateral Renal Lymphadenectomy
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Murine Bilateral Renal Lymphadenectomy

Published on: December 30, 2025

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Last Updated: Jun 8, 2026

Glomerular Outgrowth as an Ex Vivo Assay to Analyze Pathways Involved in Parietal Epithelial Cell Activation
06:39

Glomerular Outgrowth as an Ex Vivo Assay to Analyze Pathways Involved in Parietal Epithelial Cell Activation

Published on: August 19, 2020

Murine Bilateral Renal Lymphadenectomy
06:31

Murine Bilateral Renal Lymphadenectomy

Published on: December 30, 2025

Area of Science:

  • Nephrology
  • Oncology
  • Pathology

Context:

  • Neoplastic diseases can lead to direct or indirect renal damage.
  • Cancer treatments can also provoke kidney damage.
  • The link between cancer and glomerular diseases, particularly paraneoplastic glomerulonephritis, is debated.

Purpose:

  • To clarify the incidence and presentation of paraneoplastic glomerulonephritis.
  • To highlight the association between specific cancers and glomerular diseases.
  • To guide the diagnosis and management of paraneoplastic glomerulonephritis.

Summary:

  • Paraneoplastic glomerulonephritis is rare, more common in the elderly, and often associated with lung or gastrointestinal cancers.
  • Membranous nephropathy is the most common presentation.
  • Patients with unexplained nephrotic syndrome, especially older adults with membranous nephropathy or malignancy risk factors, require cancer screening.

Impact:

  • Emphasizes the need for cancer screening in patients with unexplained nephrotic syndrome.
  • Recommends prioritizing cancer treatment over immunosuppression for paraneoplastic glomerulopathy.
  • Improves understanding of the cancer-kidney disease relationship.