Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

The Parathyroid Glands

The Parathyroid Glands

The two pairs of parathyroid glands embedded within the posterior surface of the thyroid gland are restricted by a dense capsule around them. These glands comprise two distinct cell populations—parathyroid oxyphil and parathyroid principal cells- pivotal in calcium homeostasis.
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by producing...

Chronic Kidney Disease III: Interprofessional Care

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...

Factors Affecting Renal Clearance: Renal Impairment

Factors Affecting Renal Clearance: Renal Impairment

Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...

Renal Regulation of Acid-Base Balance

Renal Regulation of Acid-Base Balance

Metabolic reactions in the body produce nonvolatile acids, such as sulfuric acid, which generate an acid load of approximately 1 mEq of H+ per kilogram of body weight daily. Excreting H+ in the urine is essential to balance this acid load.
In the kidneys, cells within the proximal convoluted tubules (PCT) and the collecting ducts secrete hydrogen ions (H+) into the tubular fluid. Specifically, in the PCT, Na+/H+ antiporters secrete H+ while reabsorbing Na+.
However, the intercalated cells in...

Acute Kidney Injury II: Pathophysiology

Acute Kidney Injury II: Pathophysiology

Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...

Physiology of the Genitourinary System I: Renal Blood Flow and Glomerular Filtration

Physiology of the Genitourinary System I: Renal Blood Flow and Glomerular Filtration

The kidneys are vital organs responsible for regulating blood filtration, waste excretion, and fluid balance, all of which are crucial for maintaining homeostasis. Renal physiology examines renal blood flow, glomerular filtration, and urine formation, ensuring the body’s internal environment remains stable.Renal Blood FlowThe kidneys receive about 20-25% of the cardiac output, typically around 1200 mL of blood per minute in an average adult. Blood flows into the kidneys through the renal...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Gender differences in long-term complications of chronic hypoparathyroidism: a systematic review.

Journal of endocrinological investigation·2026

Same author

Clinical features of Italian adult individuals with X-linked hypophosphatemia: a multicenter retrospective study.

Endocrine connections·2026

Same author

Line Field Confocal Optical Coherence Tomography (LC-OCT) Features of Primary Cicatricial Alopecias.

International journal of dermatology·2026

Same author

Artificial Intelligence and Trichoscopy: Can AI Distinguish Between Alopecia Areata and Lichen Planopilaris?

International journal of dermatology·2026

Same author

Intraductal Papillary Mucinous Neoplasms and GLP-1 Receptor Agonists: Navigating Therapeutic Uncertainty in Diabetes Management.

Biomedicines·2025

Same author

Correction: Experts' consensus on the management and treatment of individuals with X-linked hypophosphatemia across lifespan.

Journal of endocrinological investigation·2025

Search research articles

Related Experiment Video

Updated: Jun 8, 2026

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy

Published on: July 14, 2023

[Renal function in primary hyperparathyroidism].

Giorgio Borretta¹, Laura Gianotti, Flora Cesario

¹S.C. di Endocrinologia e Malattie del Ricambio, ASO ''S. Croce e Carle'', Cuneo, Italy. borretta.g@ospedale.cuneo.it

Giornale Italiano Di Nefrologia : Organo Ufficiale Della Societa Italiana Di Nefrologia

|October 6, 2010

Summary

Primary hyperparathyroidism (PHPT) often presents with kidney stones. While parathyroidectomy improves kidney stones, its effect on kidney failure and the benefits of surgery for asymptomatic PHPT remain unclear.

More Related Videos

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

Published on: April 4, 2025

Related Experiment Videos

Last Updated: Jun 8, 2026

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy

Published on: July 14, 2023

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

Published on: April 4, 2025

Area of Science:

Nephrology
Endocrinology
Surgical Oncology

Context:

The kidney is a primary target organ for parathyroid hormone (PTH) action.
Symptomatic primary hyperparathyroidism (PHPT) frequently manifests with renal symptoms, notably kidney stones.
Nephrocalcinosis and polyuria are less common but associated with hypercalcemia severity.

Purpose:

To review the renal manifestations of PHPT and the impact of parathyroidectomy.
To discuss the association between PHPT and kidney failure, including morbidity and mortality risks.
To evaluate current guidelines for asymptomatic PHPT management, particularly concerning renal function.

Summary:

Parathyroidectomy significantly improves nephrolithiasis but has limited effects on nephrocalcinosis.
Kidney failure is a long-term complication linked to severe PHPT and increased mortality.
The role of PHPT in accelerating kidney function decline and the protective effect of parathyroidectomy are uncertain.

Impact:

Highlights the renal complications of PHPT and treatment outcomes.
Informs clinical decision-making for managing PHPT, especially in asymptomatic cases with renal impairment.
Underscores the need for further research into the long-term renal effects of PHPT and its surgical treatment.