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[Neoplastic polyendocrine syndromes and the kidney]
1U.O.C. di Endocrinologia, Ospedale Maggiore-Bellaria, Azienda USL, Bologna, Italy. ncremonini@alinet.it
Abstract:
Some neoplastic polyendocrine syndromes may affect the kidney. These include multiple endocrine neoplasia type 1 and 2 (MEN 1, MEN 2) as well as mixed syndromes characterized by endocrine and non-endocrine diseases. Kidney involvement may be related to secondary systemic hypertension or diabetes mellitus, direct hormonal effects, and benign or malignant kidney tumors or kidney malformations (very rare). Neoplastic polyendocrine syndromes are rare and it is important that the endocrinologist knows the possible renal complications or associated diseases for correct screening, and that the nephrologist is aware of the need for endocrinological assessment in young hypertensive patients who are resistant to therapy, hypertensive patients with adrenal lesions, and patients with hypercalciuria or renal calculi, especially at a young age.
Insights
Neoplastic polyendocrine syndromes, like multiple endocrine neoplasia (MEN 1, MEN 2), can impact the kidneys. Early recognition by endocrinologists and nephrologists is crucial for managing renal complications and associated diseases.
Area of Science:
- Endocrinology
- Nephrology
- Oncology
Context:
- Neoplastic polyendocrine syndromes, including multiple endocrine neoplasia types 1 and 2 (MEN 1, MEN 2), can manifest with significant renal involvement.
- Kidney complications arise from secondary systemic hypertension, diabetes mellitus, direct hormonal influences, and renal tumors or malformations.
Purpose:
- To highlight the potential renal manifestations of neoplastic polyendocrine syndromes.
- To emphasize the importance of interdisciplinary awareness between endocrinologists and nephrologists for timely diagnosis and management.
Summary:
- These rare syndromes necessitate vigilance for renal issues such as hypertension, diabetes, hormonal effects, and tumors.
- Endocrinologists must screen for renal complications, while nephrologists should consider endocrinological assessment in specific patient groups.
Impact:
- Facilitates earlier detection and management of kidney disease in patients with endocrine neoplasms.
- Improves patient outcomes by promoting integrated care pathways for complex endocrine-nephrological conditions.
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