Acute myeloid leukemia diagnosis in the 21st century
1Molecular Diagnostics Laboratory, University of Michigan Health System, Ann Arbor, MI 48105-3450, USA. bbetz@med.umich.edu
Context:
Rapid advances in understanding the molecular biology of acute myeloid leukemia are transforming the approach to diagnosis, prognostication, and treatment of these cases.
Objective:
To briefly review the current state of AML classification with a particular emphasis on the role of molecular studies and their impact on the management of acute myeloid leukemia and other malignancies.
Data Sources:
Current literature and experience of the authors.
Conclusions:
While morphology, immunophenotyping, cytogenetics, and clinical history continue to play an important role, an increasing number of molecular tests are now required to properly classify these cases.
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