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Lipid peroxidation in patients with schizophrenia
Anna Dietrich-Muszalska1, Bogdan Kontek
1Department of Affective and Psychotic Disorders, Medical University of Lodz, Lodz, Poland. tzn_lodz@post.pl
Psychiatry and Clinical Neurosciences
|October 7, 2010
Summary
Schizophrenia patients exhibit increased lipid peroxidation and lower antioxidant capacity. Antipsychotics olanzapine and risperidone did not cause these oxidative stress changes in vitro.
Area of Science:
- Neuroscience
- Biochemistry
- Psychiatry
Background:
- Schizophrenia is linked to free radical metabolism dysregulation and oxidative stress.
- This may lead to neuronal injury and impaired brain function.
Purpose of the Study:
- To assess total antioxidant capacity (TAC) and lipid peroxidation (TBARS) in schizophrenic patients on olanzapine or risperidone.
- To investigate the in vitro effect of these antipsychotics on lipid peroxidation.
Main Methods:
- Measured plasma TBARS and TAC in 30 schizophrenic patients and 30 healthy volunteers.
- Assessed TBARS in healthy volunteer plasma incubated with olanzapine or risperidone in vitro.
Main Results:
- Schizophrenic patients showed significantly lower TAC and higher TBARS.
- In vitro incubation with olanzapine or risperidone did not alter TBARS levels.
Conclusions:
- Pro-oxidant disturbances are present in schizophrenic patients during acute episodes.
- Olanzapine and risperidone do not appear to increase plasma lipid peroxidation.
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