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Related Concept Videos

Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
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Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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Pigmentation01:19

Pigmentation

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Related Experiment Video

Updated: Jun 8, 2026

A 3D Organotypic Melanoma Spheroid Skin Model
08:49

A 3D Organotypic Melanoma Spheroid Skin Model

Published on: May 18, 2018

Objective melanoma progression.

Pietro Rubegni1, Marco Burroni, Niccolò Nami

  • 1Department of Clinical Medicine and Immunological Science, Dermatology Section, University of Siena, Siena, Italy. rubegni@unisi.it

Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [And] International Society for Digital Imaging of Skin (ISDIS) [And] International Society for Skin Imaging (ISSI)
|October 7, 2010
PubMed
Summary
This summary is machine-generated.

Malignant melanoma (MM) lesions objectively changed over time, increasing in size and internal disorganization. These findings offer quantitative insights into melanoma

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Area of Science:

  • Dermatology and Cutaneous Oncology
  • Digital Imaging in Medicine

Background:

  • The natural history and temporal changes of malignant melanoma (MM) remain incompletely understood.
  • Objective assessment of melanoma evolution is crucial for diagnosis and management.

Purpose of the Study:

  • To retrospectively determine objective changes in malignant melanoma over a 3-24 month observation period.
  • To identify key digital dermoscopy parameters that signify melanoma modification over time.

Main Methods:

  • Retrospective evaluation of dermoscopic images from 59 MM cases across two Italian dermatology centers.
  • Utilized a digital dermoscopy analyzer (DB-Mips System) assessing 49 parameters (geometries, colors, textures, islands of color).
  • Employed multivariate analysis of variance for repeated measures to assess statistical significance of changes.

Main Results:

  • Melanoma lesions demonstrated significant increases in dimensions (Area, Minimum, and Maximum Diameter).
  • Internal components showed increased disorganization, including Red, Green, and Blue Multicomponent, Contrast, and Entropy.
  • Observed an increase in clusters of milky pink color (Light Red Area) within lesions.

Conclusions:

  • Quantitative analysis of digital dermoscopy parameters identified significant factors in melanoma modification.
  • The study provides valuable insights into the natural history of malignant melanoma through objective, measurable changes.
  • These findings can aid in understanding melanoma progression and potentially inform clinical monitoring strategies.