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Expression of estrogen-related receptor beta (ERRβ) in human skin

Elodie Krahn-Bertil1, Morgan Dos Santos, Odile Damour

  • 1Laboratoire des Substituts Cutanés, Hôpital Edouard Herriot 5 Place d'Arsonval, 69437 Lyon, France.

European Journal of Dermatology : EJD
|October 7, 2010
PubMed

Insights

Estrogen-related receptor beta (ERRβ) is newly found in human skin, specifically in epidermal cells like keratinocytes and Langerhans cells. This discovery suggests ERRβ plays a role in skin immunity and endocrine functions.

Area of Science:

  • Endocrinology
  • Dermatology
  • Molecular Biology

Background:

  • Skin properties and functions are influenced by estrogen levels, which decline during menopause.
  • Estrogen-related receptors (ERRs) are closely related to estrogen receptors (ERs) and modulate ER-mediated signaling.
  • ERRβ expression is typically found in limited adult tissues, such as the prostate and inner ear.

Purpose of the Study:

  • To investigate the presence and role of ERRβ in normal human skin.
  • To determine if ERRβ is expressed in epidermal cells.

Main Methods:

  • Immunohistochemistry was used to detect ERRβ in human skin epidermis.
  • RT-PCR and Western blotting validated ERRβ expression in cultured keratinocytes and epidermal cells.

Main Results:

  • Estrogen-related receptor beta (ERRβ) was successfully detected in the human epidermis.
  • Expression was identified in both keratinocytes and Langerhans cells within the epidermis.
  • Validation confirmed ERRβ presence in freshly extracted and cultured epidermal cells.

Conclusions:

  • This study demonstrates, for the first time, the expression of ERRβ in normal human skin.
  • The findings suggest a potential role for ERRβ in skin immunity and endocrine regulation.
  • ERRβ may represent a novel target for understanding skin's response to hormonal changes.

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