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Related Concept Videos

Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
Changes in the Appendicular Skeleton with Age01:09

Changes in the Appendicular Skeleton with Age

The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
The Functions of the Skeletal System01:22

The Functions of the Skeletal System

The most apparent functions of the skeletal system are support, protection, and movement. However, bone tissue also performs several other critical metabolic functions. For one, the bone matrix acts as a reservoir for a number of minerals important to the functioning of the body, especially calcium and phosphorus. These minerals, present in the bone tissue, can be released back into the bloodstream when required. Calcium ions, for example, are essential for muscle contractions and controlling...
Bone as Supporting Connective Tissue01:23

Bone as Supporting Connective Tissue

Bone tissue forms the internal skeleton of vertebrate animals, providing structure to the body.
Bone Matrix
Bone, or osseous tissue, is a connective tissue that has a large amount of two different types of matrix material. The organic matrix is similar to the matrix material found in other connective tissues, including some amount of collagen and elastic fibers. This gives strength and flexibility to the tissue. The inorganic matrix consists of mineral salts— mostly calcium salts— that give the...

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Cantilever Bending of Murine Femoral Necks
06:44

Cantilever Bending of Murine Femoral Necks

Published on: January 5, 2022

Aging and bone.

A L Boskey1, R Coleman

  • 1Hospital for Special Surgery, 535 E. 70th Street, New York, NY 10021, USA. boskeya@hss.edu

Journal of Dental Research
|October 7, 2010
PubMed
Summary
This summary is machine-generated.

Bone properties change throughout life, impacting mechanical function and shape. This review explores age-related bone modifications and theories behind these dynamic changes.

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Area of Science:

  • Bone biology and biomechanics.
  • Skeletal physiology and aging.

Background:

  • Bones are vital for mechanical support, protection, marrow housing, and calcium homeostasis.
  • Skeletal properties are not static and undergo significant modifications throughout an organism's lifespan.

Purpose of the Study:

  • To review age-related changes in bone mechanical function and shape.
  • To examine alterations in bone cells, matrix, and mineral composition.
  • To present current theories explaining these age-associated skeletal modifications.

Main Methods:

  • Literature review of skeletal aging research.
  • Analysis of studies on bone cell biology and extracellular matrix.
  • Synthesis of theories on factors influencing bone remodeling and adaptation.

Main Results:

  • Bone mechanical properties and shape evolve with age, with varied functional outcomes.
  • Significant changes occur in bone cells, the organic matrix, and mineral deposition.
  • Multiple factors contribute to age-dependent bone alterations.

Conclusions:

  • Skeletal aging involves complex modifications in structure and function.
  • Understanding these changes is crucial for addressing age-related bone conditions.
  • Ongoing research continues to elucidate the mechanisms driving skeletal senescence.