Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Arteries and Arterioles01:16

Arteries and Arterioles

Arteries, the vasculature responsible for transporting blood from the heart, possess robust walls capable of enduring the elevated pressures exerted by the heartbeat. Arteries near the heart are especially thick-walled and enriched with elastic fibers across their three tunics, classifying them as elastic or conducting arteries. These arteries, usually with a diameter exceeding 10 mm, are characterized by their ability to dilate in response to the blood pumped from the heart's ventricles and...
Elastin is Responsible for Tissue Elasticity01:12

Elastin is Responsible for Tissue Elasticity

Elastic fiber contains the protein elastin along with lesser amounts of other proteins and glycoproteins. The main property of elastin is that it will return to its original shape after being stretched or compressed. Elastic fibers are prominent in elastic tissues found in skin and the elastic ligaments of the vertebral column.
Ligaments and tendons are made of dense regular connective tissue, but in ligaments not all fibers are parallel. Dense regular elastic tissue contains elastin fibers and...
Aneurysm I: Introduction01:30

Aneurysm I: Introduction

An aortic aneurysm is a localized outpouching or dilation at a weak point in the artery wall. It may involve different parts of the aorta, such as the abdominal aorta, aortic arch, or thoracic aorta.Etiological factorsSeveral disorders are associated with aortic aneurysms.Congenital causes, such as primary connective tissue disorders like Marfan syndrome, impact the integrity and strength of connective tissues, notably affecting the aorta. Marfan syndrome is a genetic disorder that specifically...
Fibrous Proteins00:55

Fibrous Proteins

Fibrous proteins are either long and narrow proteins or assemble to form long and thin structures. They contain repetitive units and usually consist of either alpha helices or beta sheets and, in rare cases, a mix of both. The amino acids in the primary structure often consist of repeating amino acid sequences. The role of fibrous proteins is primarily structural. Many are located in the extracellular matrix and are present in connective tissues to impart strength and joint mobility. They are...
Dense Connective Tissue01:13

Dense Connective Tissue

Dense connective tissue contains more collagen fibers than loose connective tissue. As a consequence, it displays greater resistance to stretching. There are two major categories of dense connective tissue— regular and irregular.
Dense Regular Connective Tissue
In dense regular connective tissue, fibers are arranged parallel to each other, enhancing its tensile strength and resistance to stretching in the direction of the fiber orientations. Ligaments and tendons are made of dense regular...
Structure of Blood Vessels01:15

Structure of Blood Vessels

Blood is circulated throughout the human body through a network of blood vessels called the circulatory system. This system includes arteries that transport blood from the heart to various body parts. These arterial pathways divide into smaller vessels until they reach the arterioles, which further split into capillaries. It is within these minuscule capillaries that the exchange of nutrients and waste products takes place. After this exchange, the blood is collected by venules, which fuse to...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Occupational injuries in Canadian youth: an analysis of 22 years of surveillance data collected from the Canadian Hospitals Injury Reporting and Prevention Program.

Health promotion and chronic disease prevention in Canada : research, policy and practice·2016
Same author

Childhood exposure to ambient polycyclic aromatic hydrocarbons is linked to epigenetic modifications and impaired systemic immunity in T cells.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2014
Same author

Salivary gland toxicity after radioiodine therapy for thyroid cancer.

Clinical oncology (Royal College of Radiologists (Great Britain))·2007
Same author

Anti-inflammatory effects of once daily low dose inhaled ciclesonide in mild to moderate asthmatic patients.

Allergy·2006
Same author

Prognosis for fertility and ovarian function after treatment with radioiodine for thyroid cancer.

Postgraduate medical journal·2002
Same author

Initial results with an electrothermal bipolar vessel sealer.

Surgical endoscopy·2001

Related Experiment Video

Updated: Jun 8, 2026

Assessing Collagen and Elastin Pressure-dependent Microarchitectures in Live, Human Resistance Arteries by Label-free Fluorescence Microscopy
09:58

Assessing Collagen and Elastin Pressure-dependent Microarchitectures in Live, Human Resistance Arteries by Label-free Fluorescence Microscopy

Published on: April 9, 2018

Arterial elastic fiber structure. Function and potential roles in acute aortic dissection.

B Pratt1, J Curci

  • 1Section of Vascular Surgery, Department of Surgery Washington University School of Medicine, St. Louis MO 63131, USA.

The Journal of Cardiovascular Surgery
|October 7, 2010
PubMed
Summary

Understanding aortic dissection requires examining elastic fiber failure. Increased transforming growth factor-β (TGF-β) and matrix metalloproteinases (MMPs) contribute to dissection risk and progression.

More Related Videos

Measuring Ascending Aortic Stiffness In Vivo in Mice Using Ultrasound
10:08

Measuring Ascending Aortic Stiffness In Vivo in Mice Using Ultrasound

Published on: December 2, 2014

Manufacturing Abdominal Aorta Hydrogel Tissue-Mimicking Phantoms for Ultrasound Elastography Validation
09:32

Manufacturing Abdominal Aorta Hydrogel Tissue-Mimicking Phantoms for Ultrasound Elastography Validation

Published on: September 19, 2018

Related Experiment Videos

Last Updated: Jun 8, 2026

Assessing Collagen and Elastin Pressure-dependent Microarchitectures in Live, Human Resistance Arteries by Label-free Fluorescence Microscopy
09:58

Assessing Collagen and Elastin Pressure-dependent Microarchitectures in Live, Human Resistance Arteries by Label-free Fluorescence Microscopy

Published on: April 9, 2018

Measuring Ascending Aortic Stiffness In Vivo in Mice Using Ultrasound
10:08

Measuring Ascending Aortic Stiffness In Vivo in Mice Using Ultrasound

Published on: December 2, 2014

Manufacturing Abdominal Aorta Hydrogel Tissue-Mimicking Phantoms for Ultrasound Elastography Validation
09:32

Manufacturing Abdominal Aorta Hydrogel Tissue-Mimicking Phantoms for Ultrasound Elastography Validation

Published on: September 19, 2018

Area of Science:

  • Cardiovascular Biology
  • Molecular Medicine
  • Connective Tissue Disorders

Background:

  • Acute aortic dissection is a life-threatening condition.
  • Understanding the molecular basis of aortic dissection is crucial for effective treatment and prevention.
  • Elastic fibers are key structural components of the aortic wall, and their failure is implicated in dissection.

Purpose of the Study:

  • To review the role of elastic fibers in aortic dissection.
  • To explore the molecular mechanisms predisposing to dissection, including genetic factors and growth factor activity.
  • To discuss the pathological events leading to post-dissection aortic degeneration and potential therapeutic strategies.

Main Methods:

  • Literature review focusing on molecular and physiological events in aortic dissection.
  • Analysis of research on hereditary conditions like Marfan syndrome.
  • Examination of the role of transforming growth factor-β (TGF-β) and matrix metalloproteinases (MMPs).

Main Results:

  • Failure of elastic fibers in the aortic wall contributes to dissection and aneurysm formation.
  • Altered scaffolding proteins and increased TGF-β activity are implicated in hereditary aortic dissection.
  • Matrix degradation by MMPs, such as MMP-9, exacerbates post-dissection aortic damage.

Conclusions:

  • Therapeutic inhibition of TGF-β shows promise for reducing dissection risk in high-risk individuals.
  • Targeting molecular pathways involved in elastic fiber integrity and matrix remodeling may offer novel treatment strategies.
  • Further research into the molecular underpinnings of aortic dissection is essential for developing preventative and therapeutic interventions.