Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Tissues01:18

Tissues

Cells with similar structure and function are grouped into tissues. A group of tissues with a specialized function is called an organ. There are four main types of tissue in vertebrates: epithelial, connective, muscle, and nervous.
Tissues01:25

Tissues

Tissues are a group of cells that share a common embryonic origin. Microscopic observation reveals that the cells in a tissue share morphological features and are arranged in an orderly pattern to perform specific functions. From an evolutionary perspective, tissues appear in more complex organisms. Although there are many types of cells in the human body, they are organized into four broad categories of tissues: epithelial, connective, muscle, and nervous. Each of these categories is...
Levels of Organization01:09

Levels of Organization

Biological organization is the classification of biological structures, ranging from atoms at the bottom of the hierarchy to the Earth's biosphere. Each level of the hierarchy represents an increase in complexity that builds upon the previous level.Molecules Are Composed of Atoms, and Biomolecules Are Assembled from Molecules:The most basic levels include atoms, molecules, and biomolecules. Atoms, the smallest unit of ordinary matter, are composed of a nucleus and electrons. Molecules comprise...
Structural Organization of the Human Body: An Overview01:18

Structural Organization of the Human Body: An Overview

It is convenient to consider the body's structures in terms of fundamental levels of organization that increase in complexity: subatomic particles, atoms, molecules, organelles, cells, tissues, organs, organ systems, and organisms.
To study the chemical level of organization, scientists consider the simplest building blocks of matter: subatomic particles, atoms, and molecules. All matter in the universe is composed of one or more unique pure substances called elements, familiar examples of...
Cadherins in Tissue Organization01:19

Cadherins in Tissue Organization

The cadherins are a superfamily of cell adhesion molecules comprising over 180 variants, with specific tissues expressing a particular combination of cadherin types. Cadherins generally exhibit homophilic binding; i.e., cadherins on one cell bind to cadherins of the same or closely related type on another cell. Thus, cells of the same type have a specific affinity to bind to each other and sort themselves into clusters to form tissues.
Cell Sorting During Development
Cell sorting plays an...
Protein Networks02:26

Protein Networks

An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

High-resolution spatial transcriptomics of adult and pediatric human liver with Visium HD.

Scientific data·2026
Same author

Development of an Agent-Based Model to Investigate Durability of Factor IX Activity in Hemophilia B Patients Treated With Etranacogene Dezaparvovec.

CPT: pharmacometrics & systems pharmacology·2026
Same author

Standardized Pediatric Outcome Measures in Physical Therapy Part 2: Clinical and Academic Perspectives.

Pediatric physical therapy : the official publication of the Section on Pediatrics of the American Physical Therapy Association·2026
Same author

Global genetic interaction network of a human cell maps conserved principles and informs functional interpretation of gene co-essentiality profiles.

Cell·2026
Same author

Metabolomic Signatures of Relapse and Survival in AML Patients Receiving Allogeneic Hematopoietic Stem Cell Transplantation.

Hematology reports·2026
Same author

From FAIR to CURE: guidelines for computational models of biological systems.

NPJ systems biology and applications·2026
Same journal

Thermo-flux: generation and analysis of thermodynamic-stoichiometric metabolic network models.

Molecular systems biology·2026
Same journal

Paradoxical non-catalytic kinase functions are driven by inhibitor-induced displacement of autoinhibitory domains.

Molecular systems biology·2026
Same journal

E. coli prepares for starvation by dramatically remodeling its proteome in the first hours after loss of nutrients.

Molecular systems biology·2026
Same journal

Common xenobiotics modulate gut microbial responses to low‑calorie sweeteners in vitro.

Molecular systems biology·2026
Same journal

ParTIpy: a scalable framework for archetypal analysis and Pareto task inference.

Molecular systems biology·2026
Same journal

Quantitative interactome mapping of skeletal muscle insulin resistance.

Molecular systems biology·2026
See all related articles

Related Experiment Video

Updated: Jun 8, 2026

Design, Surface Treatment, Cellular Plating, and Culturing of Modular Neuronal Networks Composed of Functionally Inter-connected Circuits
10:32

Design, Surface Treatment, Cellular Plating, and Culturing of Modular Neuronal Networks Composed of Functionally Inter-connected Circuits

Published on: April 15, 2015

Dynamic interaction networks in a hierarchically organized tissue.

Daniel C Kirouac1, Caryn Ito, Elizabeth Csaszar

  • 1Institute for Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada.

Molecular Systems Biology
|October 7, 2010
PubMed
Summary
This summary is machine-generated.

Stem cell communication networks are crucial for development. This study reveals how specific growth factors and inhibitory signals from differentiated cells regulate blood stem cell self-renewal and fate decisions.

More Related Videos

Anatomically Inspired Three-dimensional Micro-tissue Engineered Neural Networks for Nervous System Reconstruction, Modulation, and Modeling
10:45

Anatomically Inspired Three-dimensional Micro-tissue Engineered Neural Networks for Nervous System Reconstruction, Modulation, and Modeling

Published on: May 31, 2017

Engineering Three-dimensional Epithelial Tissues Embedded within Extracellular Matrix
08:49

Engineering Three-dimensional Epithelial Tissues Embedded within Extracellular Matrix

Published on: July 10, 2016

Related Experiment Videos

Last Updated: Jun 8, 2026

Design, Surface Treatment, Cellular Plating, and Culturing of Modular Neuronal Networks Composed of Functionally Inter-connected Circuits
10:32

Design, Surface Treatment, Cellular Plating, and Culturing of Modular Neuronal Networks Composed of Functionally Inter-connected Circuits

Published on: April 15, 2015

Anatomically Inspired Three-dimensional Micro-tissue Engineered Neural Networks for Nervous System Reconstruction, Modulation, and Modeling
10:45

Anatomically Inspired Three-dimensional Micro-tissue Engineered Neural Networks for Nervous System Reconstruction, Modulation, and Modeling

Published on: May 31, 2017

Engineering Three-dimensional Epithelial Tissues Embedded within Extracellular Matrix
08:49

Engineering Three-dimensional Epithelial Tissues Embedded within Extracellular Matrix

Published on: July 10, 2016

Area of Science:

  • Stem cell biology
  • Cellular communication networks
  • Hematopoiesis

Background:

  • Intercellular communication is vital for multicellular organisms, maintaining homeostasis and coordinating development.
  • The precise rules, structure, and molecular underpinnings of stem cell communication networks remain largely unknown.
  • Understanding these networks is critical for stem cell biology and regenerative medicine.

Purpose of the Study:

  • To elucidate the structure and dynamics of intercellular and intracellular networks in human umbilical cord blood progenitors.
  • To identify the molecular mechanisms by which secreted factors regulate stem cell fate decisions, particularly self-renewal.
  • To characterize the signaling nodes that integrate extracellular and intracellular communication in stem cells.

Main Methods:

  • Integrated high-throughput molecular profiling, database and literature mining.
  • Mechanistic modeling and in vitro cell culture experiments using human umbilical cord blood progenitors.
  • Experimental and theoretical analyses of intercellular and intracellular signaling pathways.

Main Results:

  • Secreted factor-mediated intercellular communication networks significantly regulate blood stem cell fate decisions.
  • A coupled positive-negative feedback circuit involving megakaryocyte-derived stimulatory factors (e.g., VEGF, PDGF) and monocyte-derived inhibitory factors (e.g., CCL3, TGFB2) modulates stem cell self-renewal.
  • Reconstructed intracellular network identified PI3K, Raf, Akt, and PLC as key signal integration nodes linking extracellular and intracellular signaling.

Conclusions:

  • Stem cell fate decisions are regulated non-autonomously through lineage-specific interactions with differentiated progeny.
  • This study provides the first systematic characterization of intercellular feedback circuits governing stem cell self-renewal.
  • The identified signaling nodes offer potential targets for therapeutic interventions in stem cell biology and regenerative medicine.