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Related Concept Videos

Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Treatment Resistent Cancers02:56

Treatment Resistent Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...

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Updated: Jun 8, 2026

In Vivo Model for Testing Effect of Hypoxia on Tumor Metastasis
12:03

In Vivo Model for Testing Effect of Hypoxia on Tumor Metastasis

Published on: December 9, 2016

Chemotherapy in Ewing's sarcoma.

Sandeep Jain1, Gauri Kapoor

  • 1Department of Pediatric Hematology and Oncology, Rajiv Gandhi Cancer Institute and Research Centre, Delhi, India.

Indian Journal of Orthopaedics
|October 7, 2010
PubMed
Summary
This summary is machine-generated.

Ewing's sarcoma, a rare pediatric cancer, shows improved survival with chemotherapy and local treatments for localized cases. However, outcomes for metastatic or recurrent disease remain poor, necessitating new therapeutic strategies.

Keywords:
Ewing’s sarcomachemotherapymetastasis

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Area of Science:

  • Pediatric Oncology
  • Medical Oncology
  • Cancer Research

Background:

  • Ewing's sarcoma is a rare but aggressive bone and soft tissue cancer affecting children.
  • It represents 3% of all pediatric malignancies.
  • While chemotherapy has improved outcomes, challenges remain for advanced disease stages.

Purpose of the Study:

  • To review current treatment strategies for Ewing's sarcoma.
  • To highlight the efficacy of combined chemotherapy and local control.
  • To emphasize the need for novel therapies for metastatic and refractory cases.

Main Methods:

  • Review of existing literature and clinical trial data.
  • Analysis of treatment responses based on disease stage (localized vs. metastatic).
  • Evaluation of survival rates associated with current multimodal approaches.

Main Results:

  • Combined chemotherapy, surgery, and radiotherapy yield a 70% survival rate for localized Ewing's sarcoma.
  • Chemotherapy is a cornerstone treatment, showing better response than in adult sarcomas.
  • Outcomes for patients with metastatic, recurrent, or refractory Ewing's sarcoma remain significantly poor.

Conclusions:

  • Multimodal therapy including chemotherapy, surgery, and radiotherapy has improved survival for localized Ewing's sarcoma.
  • There is a critical unmet need for innovative treatments to improve outcomes in metastatic and refractory Ewing's sarcoma.
  • Further research and cooperative group trials are essential to develop and test new therapeutic approaches.