Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

Modified-Release Drug Delivery Systems: Stimuli-Activated

Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Engineering nanoparticle surface chemistry for antigen-presenting cell targeting improves specificity and safety of TLR3 agonist cancer immunotherapy.

bioRxiv : the preprint server for biology·2026
Same author

Polyelectrolyte nanoparticles enable intracellular delivery of STING protein fragments for ovarian cancer immunotherapy.

Materials today. Bio·2026
Same author

A multivalent peptide-polymer conjugate material mimics STING to therapeutically activate innate immune signaling.

bioRxiv : the preprint server for biology·2026
Same author

PEG chains modulate electrostatic interactions between PAMAM and articular cartilage.

Biomaterials·2026
Same author

Bacterial enzyme-responsive hydrogels for triggered delivery of antibiotics to infected wounds.

Science advances·2026
Same author

Dual Biomolecule Patterning on Micropatterned Polylactide Surfaces Bearing Oppositely Charged Polymer Brushes at Neighboring Sites.

ACS biomaterials science & engineering·2026

Related Experiment Video

Updated: Jun 8, 2026

Nanomechanics of Drug-target Interactions and Antibacterial Resistance Detection
11:56

Nanomechanics of Drug-target Interactions and Antibacterial Resistance Detection

Published on: October 25, 2013

Tunable vancomycin releasing surfaces for biomedical applications.

Anita Shukla1, Sareena N Avadhany, Jean C Fang

  • 1Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.

Small (Weinheim an Der Bergstrasse, Germany)
|October 7, 2010
PubMed
Summary
This summary is machine-generated.

This study developed polymer multilayer films for local vancomycin delivery, achieving high drug densities and tunable release profiles. These coatings effectively inhibit Staphylococcus aureus growth, offering versatile solutions for infection control.

More Related Videos

Transforming Static Barrier Tissue Models into Dynamic Microphysiological Systems
06:20

Transforming Static Barrier Tissue Models into Dynamic Microphysiological Systems

Published on: February 16, 2024

High-throughput Identification of Bacteria Repellent Polymers for Medical Devices
10:43

High-throughput Identification of Bacteria Repellent Polymers for Medical Devices

Published on: November 5, 2016

Related Experiment Videos

Last Updated: Jun 8, 2026

Nanomechanics of Drug-target Interactions and Antibacterial Resistance Detection
11:56

Nanomechanics of Drug-target Interactions and Antibacterial Resistance Detection

Published on: October 25, 2013

Transforming Static Barrier Tissue Models into Dynamic Microphysiological Systems
06:20

Transforming Static Barrier Tissue Models into Dynamic Microphysiological Systems

Published on: February 16, 2024

High-throughput Identification of Bacteria Repellent Polymers for Medical Devices
10:43

High-throughput Identification of Bacteria Repellent Polymers for Medical Devices

Published on: November 5, 2016

Area of Science:

  • Biomaterials Science
  • Drug Delivery Systems
  • Polymer Chemistry

Background:

  • Local drug delivery minimizes systemic toxicity by concentrating therapeutics at infection sites.
  • Vancomycin hydrochloride is a potent antibiotic crucial for combating serious bacterial infections.

Purpose of the Study:

  • To engineer vancomycin hydrochloride delivery coatings using layer-by-layer assembly.
  • To control drug loading and release kinetics for localized infection treatment.

Main Methods:

  • Utilized layer-by-layer (LbL) assembly via spray and dip coating techniques.
  • Incorporated vancomycin hydrochloride into polymer multilayer films, controlling interdiffusion for drug integration.
  • Engineered composite film architectures for varied release profiles.

Main Results:

  • Achieved high vancomycin densities (17-220 μg mm⁻³) in micron to submicron scale films.
  • Demonstrated controlled drug release over 4 hours to 2.5 days.
  • Exhibited potent inhibition of Staphylococcus aureus growth in vitro.
  • Developed composite films with bolus followed by sustained release.

Conclusions:

  • LbL assembly offers precise control over drug loading and release kinetics for vancomycin coatings.
  • Engineered coatings provide effective localized antibiotic delivery, adaptable to different clinical needs.
  • This approach holds promise for advanced localized infection management strategies.