Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Structure of Amines01:19

Structure of Amines

The hybridized nitrogen atom in amines possesses a lone pair of electrons and is bound to three substituents with a bond angle of around 108°, which is less than the tetrahedral angle of 109.5°. However, the C–N–H bond angle is slightly larger at 112°, with a carbon–nitrogen bond length of 147 pm. This carbon–nitrogen bond length of of amines is longer than the carbon–oxygen bond of alcohols (143 pm) but shorter than alkanes’ carbon–carbon bond (154 pm). These aspects are illustrated in Figure...
Adrenergic Agonists: Chemistry and Structure-Activity Relationship01:16

Adrenergic Agonists: Chemistry and Structure-Activity Relationship

Adrenergic agonists' structure-activity relationship (SAR) determines their selectivity and efficacy. These agonists comprise a phenylethylamine moiety with an aromatic ring and an ethylamine side chain.
Aromatic ring substitutions: Substituting the aromatic ring with –OH groups at positions 3 and 4 yields catecholamines (e.g., epinephrine), which have a high affinity for adrenoceptors. Hydrogen bonding between –OH groups and receptors enhances adrenergic activity.
Separation of the aromatic...
Structures of Carboxylic Acid Derivatives01:28

Structures of Carboxylic Acid Derivatives

Structure of Carboxylic Acid Derivatives
Carboxylic acid derivatives contain an acyl group attached to a heteroatom such as chlorine, oxygen, or nitrogen. The carbonyl carbon and oxygen are both sp2-hybridized with an unhybridized p orbital.
The three sp2 orbitals of the carbonyl carbon form three σ bonds, one each with the carbonyl oxygen, the α carbon, and the heteroatom, whereas the other two sp2 orbitals of the carbonyl oxygen are occupied by the lone pairs. Further, the unhybridized p...
[3,3] Sigmatropic Rearrangement of 1,5-Dienes: Cope Rearrangement01:21

[3,3] Sigmatropic Rearrangement of 1,5-Dienes: Cope Rearrangement

The Cope rearrangement is classified as a [3,3] sigmatropic shift in 1,5-dienes, leading to a more stable, isomeric 1,5-diene. The reaction involves a concerted movement of six electrons, four from two π bonds and two from a σ bond, via an energetically favorable chair-like transition state.
Nomenclature of Primary Amines01:17

Nomenclature of Primary Amines

Primary, secondary, and tertiary amines are compounds consisting of one, two, and three alkyl groups connected to the amino group (–NH2), respectively. As depicted in Figure 1, the common name of the primary amines is obtained by adding the suffix -amine to the alkyl substituent attached to the amino group as the corresponding alkylamine.
Chair Conformation of Cyclohexane02:02

Chair Conformation of Cyclohexane

The chair conformation is the most stable form of cyclohexane due to the absence of angle and torsional strain. The absence of angle strain is a result of cyclohexane’s bond angle being very close to the ideal tetrahedral bond angle of 109.5° in its chair conformer. Similarly, the torsional strain is also absent owing to the perfectly staggered arrangement of bonds.
The hydrogen atoms linked to carbons are arranged in two different axial and equatorial orientations to achieve this staggered...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Substituent-Dependent Structural Trends in Thermal Condensation of Silanetriols and Disiloxanetetraols.

Chemistry (Weinheim an der Bergstrasse, Germany)·2026
Same author

Dual Modality and Site-differentiated Sentinel Node Mapping in Vulvar Cancer.

Anticancer research·2026
Same author

A General Strategy for the Synthesis of Jerangolids Enabled by π-allyl Stille Coupling.

Chemistry (Weinheim an der Bergstrasse, Germany)·2026
Same author

Flash Communication: (Ph<sub>3</sub>P)<sub>2</sub>N<sub>2</sub>Aza-Wittig Reagent for Metal Carbonyls.

Organometallics·2026
Same author

Pentasilacyclopentadienide: A Hückel aromatic species at the border of resonance and equilibrium.

Science (New York, N.Y.)·2026
Same author

Microbial Cross-Talk: Unlocking the Cytochalasin Diversity from a Termite-Associated <i>Xylaria</i>.

JACS Au·2026
Same journal

Thermally Induced In-Lattice Cation Transformation of 0D Antimony Halides for Improved X-ray Scintillation.

Inorganic chemistry·2026
Same journal

Low-Valent Rhodium and Iridium Assemblies Directed by Uracilate and Guaninate Linkers.

Inorganic chemistry·2026
Same journal

Solid-State Syntheses, Crystallographic Spatial Disorders, Thermal Behavior, and Bandgaps of Hybrid Organic-Inorganic Manganese Halides: A<sub>2</sub>Mn(Cl/Br)<sub>4</sub> (A = NH<sub>4</sub>, C(NH<sub>2</sub>)<sub>3</sub>, & C<sub>3</sub>H<sub>4</sub>N<sub>2</sub>).

Inorganic chemistry·2026
Same journal

Comparing the Photophysical Properties of Bridged and Unbridged Platinum(II) Cyclometalated Complexes.

Inorganic chemistry·2026
Same journal

Solvent Coordination-Induced Synergistic Phase, Facet, and Defect Engineering of CdS for Photocatalytic Hydrogen Evolution.

Inorganic chemistry·2026
Same journal

Tailoring the Electron-Enriched Microenvironment of UiO-66 via Thiol Functionalization to Boost Non-Thermal Plasma CO<sub>2</sub> Conversion.

Inorganic chemistry·2026
See all related articles

Related Experiment Video

Updated: Jun 8, 2026

Construction and Systematical Symmetric Studies of a Series of Supramolecular Clusters with Binary or Ternary Ammonium Triphenylacetates
06:35

Construction and Systematical Symmetric Studies of a Series of Supramolecular Clusters with Binary or Ternary Ammonium Triphenylacetates

Published on: February 15, 2016

Facially coordinating triamine ligands with a cyclic backbone: some structure-stability correlations.

Christian Neis1, David Petry, Alexandre Demangeon

  • 1Anorganische Chemie, Universität des Saarlandes, Postfach 15 11 50, D-66041 Saarbrücken, Germany.

Inorganic Chemistry
|October 8, 2010
PubMed
Summary
This summary is machine-generated.

This study investigates metal complex formation using two cyclic triamines, 6-methyl-1,4-diazepan-6-amine (MeL(a)) and trimethyl-cis-cyclohexanetriamine (Me(3)tach). Me(3)tach forms highly stable metal complexes, unlike MeL(a) due to ligand strain.

More Related Videos

Constructing Cyclic Peptides Using an On-Tether Sulfonium Center
07:11

Constructing Cyclic Peptides Using an On-Tether Sulfonium Center

Published on: September 28, 2022

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides
07:26

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides

Published on: November 21, 2013

Related Experiment Videos

Last Updated: Jun 8, 2026

Construction and Systematical Symmetric Studies of a Series of Supramolecular Clusters with Binary or Ternary Ammonium Triphenylacetates
06:35

Construction and Systematical Symmetric Studies of a Series of Supramolecular Clusters with Binary or Ternary Ammonium Triphenylacetates

Published on: February 15, 2016

Constructing Cyclic Peptides Using an On-Tether Sulfonium Center
07:11

Constructing Cyclic Peptides Using an On-Tether Sulfonium Center

Published on: September 28, 2022

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides
07:26

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides

Published on: November 21, 2013

Area of Science:

  • Coordination Chemistry
  • Inorganic Chemistry
  • Supramolecular Chemistry

Background:

  • Cyclic triamines are crucial ligands in coordination chemistry.
  • Understanding ligand structure and its impact on metal complex stability is essential.
  • Previous studies on similar ligands provide context for this investigation.

Purpose of the Study:

  • To investigate the metal complex formation of 6-methyl-1,4-diazepan-6-amine (MeL(a)) and all-cis-2,4,6-trimethylcyclohexane-1,3,5-triamine (Me(3)tach).
  • To elucidate the structural and electronic properties of these ligands and their metal complexes.
  • To compare the coordination behavior and stability of MeL(a) and Me(3)tach complexes.

Main Methods:

  • pH-dependent NMR spectroscopy and X-ray diffraction for ligand structure determination.
  • Single crystal X-ray analysis for characterizing various metal complexes.
  • Potentiometric, spectrophotometric, and cyclovoltammetric measurements for stability and redox potentials.
  • Molecular mechanics calculations to assess ligand strain.

Main Results:

  • Me(3)tach exhibits a chair conformation with axial nitrogen atoms in its protonated form and is a stronger base than its parent compound.
  • MeL(a) forms complexes with low stability, comparable to its parent ligand, often involving protonated species.
  • Me(3)tach forms highly stable [M(II)L](2+) complexes (M = Cu, Zn) via an 'all-or-nothing' coordination process.
  • Molecular mechanics reveal significant torsional strain in the diazepane ring of MeL(a) limits complex stability, unlike Me(3)tach where strain is pre-formed.

Conclusions:

  • Ligand structure, particularly ring conformation and inherent strain, dictates metal complex stability.
  • Me(3)tach's pre-formed strain facilitates highly stable metal complex formation.
  • MeL(a)'s flexible diazepane ring and associated torsional strain result in less stable complexes.