Related Experiment Video
Updated: Jun 8, 2026

Advanced 3D Liver Models for In vitro Genotoxicity Testing Following Long-Term Nanomaterial Exposure
Published on: June 5, 2020
Possible genotoxic mechanisms of nanoparticles: criteria for improved test strategies
Ken Donaldson1, Craig A Poland, Roel P F Schins
1ELEGI Colt Laboratory, MRC Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, Scotland, UK. ken.donaldson@ed.ac.uk
Abstract:
We review the mechanisms and pathways whereby nanoparticles might cause genotoxicity. Primary and secondary mechanisms are discussed in relation to the general particle toxicology paradigm. We also discuss how we might improve genotoxicity assays for nanoparticles. In this context we describe the role of the dispersion and the protein corona, the most relevant metric, choice of controls and new endpoints for genotoxicity along with the need for a structure activity model of NP genotoxicity.
Related Concept Videos
Mutagenicity and Carcinogenicity
Toxicity Testing in Animals

