[Synthesis of analogs of cephalotaxine esters and their antitumor activities]

¹Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing.

Yao Xue Xue Bao = Acta Pharmaceutica Sinica

|January 1, 1990

Abstract:

Four analogs of cephalotaxine esters (C1Z, C2E, C3E, C4E) were synthesized. The ratio of the Z, E isomers of the side chain alpha, beta-unsaturated ester carboxylic acids is reported. The Z isomer was easy to transform to the E isomer. Compound C1Z showed significant activity of inducing cancer cell HL-60 differentiation. It also showed inhibitory activity on Leukemia L1210.

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