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Related Experiment Video

Updated: Jun 8, 2026

3D Modeling of the Lateral Ventricles and Histological Characterization of Periventricular Tissue in Humans and Mouse
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Spinal meningiomas: age-related features.

F Maiuri1, M L Del Basso De Caro, O de Divitiis

  • 1Department of Neurological Sciences, Neurosurgical Clinic, Federico II University of Naples, Italy. frmaiuri@yahoo.it

Clinical Neurology and Neurosurgery
|October 8, 2010
PubMed
Summary
This summary is machine-generated.

Younger adults with spinal meningiomas have a higher incidence of tumors in the high cervical spine and lower rates in the thoracic region compared to older patients. Histology and recurrence rates show no significant differences between age groups.

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Area of Science:

  • Neurosurgery
  • Oncology
  • Spinal Cord Surgery

Background:

  • Spinal meningiomas are tumors typically affecting older individuals, with a notable prevalence in females.
  • This study focuses on comparing the characteristics of spinal meningiomas in younger versus older adult patients.

Purpose of the Study:

  • To investigate and compare distinct features of spinal meningiomas between younger (<50 years) and older (≥50 years) adult patient groups.
  • To analyze differences in tumor location, histology, recurrence rates, and proliferation indices based on age.

Main Methods:

  • A retrospective review of 120 adult patients with spinal meningiomas treated surgically.
  • Patients were divided into two groups: younger than 50 years (Group I, n=30) and older than 50 years (Group II, n=87).
  • Comparison of parameters including sex, predisposing factors, tumor location, histology, recurrence, Ki-67 labeling index (LI), and outcomes.

Main Results:

  • Younger patients (Group I) showed a higher incidence of high cervical spine meningiomas (23.3% vs 3.4%) and a lower rate of thoracic tumors (60% vs 82.7%) compared to older patients (Group II).
  • No significant differences were observed in histological type or Ki-67 LI between the groups.
  • Atypical meningiomas were found in 6.6% of Group I versus 0% of Group II. Recurrence rates were 6.6% in Group I and 2.6% in Group II, not statistically significant.

Conclusions:

  • Younger adult patients with spinal meningiomas present with a higher frequency of high cervical and lower frequency of thoracic tumors compared to older patients.
  • The occurrence of neurofibromatosis was noted in 9% of younger patients.
  • Histology, Ki-67 LI, and overall recurrence rates did not differ significantly between the age groups, with a slight trend towards more atypical meningiomas in younger patients.