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Plasmonic Trapping and Release of Nanoparticles in a Monitoring Environment
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Nanostructured digital microfluidics for enhanced surface plasmon resonance imaging.

Lidija Malic1, Teodor Veres, Maryam Tabrizian

  • 1Biomedical Engineering Department, McGill University, Montreal, QC, Canada, H3A 2B4.

Biosensors & Bioelectronics
|October 8, 2010
PubMed
Summary

This study introduces a digital microfluidic platform with nanostructured biosensors for enhanced surface plasmon resonance imaging (SPRi). The system enables rapid, sensitive, and automated detection of biomarkers, improving diagnostic capabilities.

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Analytical Chemistry

Background:

  • Genomics and proteomics offer numerous biomarkers for disease diagnosis.
  • Current biosensor development focuses on rapid, label-free, and sensitive detection.
  • Surface plasmon resonance imaging (SPRi) shows promise but faces limitations in sensitivity and sample processing.

Purpose of the Study:

  • To enhance sample handling and sensitivity of SPRi detection.
  • To develop a digital microfluidic platform integrated with a nanostructured biosensor interface.
  • To enable rapid, ultra-low volume, sensitive, and automated on-chip SPRi detection of DNA hybridization.

Main Methods:

  • Implemented a digital microfluidic platform with nanostructured gold nanoposts.
  • Utilized electromagnetic properties of nanoposts to enhance SPRi signal.
  • Developed automated on-chip SPRi detection for DNA hybridization reactions.

Main Results:

  • Achieved a 200% increase in SPRi signal using nanofabricated gold nanoposts.
  • Established an estimated limit of detection of 500 pM (90 attomoles).
  • Enabled rapid, parallel target identification in 1 minute using 180 nL sample volumes.

Conclusions:

  • The digital microfluidic platform significantly enhances SPRi sensitivity and sample handling.
  • The system allows for rapid, automated, and low-volume detection suitable for diagnostics.
  • Reduced assay time, cost, and complexity through versatile microfluidic manipulation.