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Updated: Jun 8, 2026

Influenza A Virus Studies in a Mouse Model of Infection
Published on: September 7, 2017
Mice lacking alpha/beta and gamma interferon receptors are susceptible to junin virus infection
Olga A Kolokoltsova1, Nadezda E Yun, Allison L Poussard
1Galveston National Laboratory, Department of Pathology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555-1019, USA.
Abstract:
Junin virus (JUNV) causes a highly lethal human disease, Argentine hemorrhagic fever. Previous work has demonstrated the requirement for human transferrin receptor 1 for virus entry, and the absence of the receptor was proposed to be a major cause for the resistance of laboratory mice to JUNV infection. In this study, we present for the first time in vivo evidence that the disruption of interferon signaling is sufficient to generate a disease-susceptible mouse model for JUNV infection. After peripheral inoculation with virulent JUNV, adult mice lacking alpha/beta and gamma interferon receptors developed disseminated infection and severe disease.
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