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Related Concept Videos

Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...
Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...
Biological Clocks and Seasonal Responses02:45

Biological Clocks and Seasonal Responses

The circadian—or biological—clock is an intrinsic, timekeeping, molecular mechanism that allows plants to coordinate physiological activities over 24-hour cycles called circadian rhythms. Photoperiodism is a collective term for the biological responses of plants to variations in the relative lengths of dark and light periods. The period of light-exposure is called the photoperiod.
Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response01:15

Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response

Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
Understanding Sleep01:11

Understanding Sleep

Sleep, an essential biological state, involves significant reductions in physical activity, sensory awareness, and interaction with the environment. This complex physiological process is primarily regulated by specific brain regions, notably the hypothalamus and pons, which govern the sleep-wake cycle or circadian rhythm.
The circadian rhythm, a nearly 24-hour cycle, is deeply influenced by environmental light cues. Light exposure directly affects the hypothalamus, which in turn regulates...
Sleep-Wake Cycles01:24

Sleep-Wake Cycles

Sleep is an essential physiological process vital to maintaining overall well-being. The reticular activating system (RAS), a network of neurons in the brainstem, regulates wakefulness and sleep. While it may seem passive, sleep consists of distinct cycles, each with its unique characteristics and functions. Two key sleep phases are non-rapid eye movement (NREM) and  rapid eye movement (REM).
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:

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Updated: Jun 8, 2026

Monitoring Cell-autonomous Circadian Clock Rhythms of Gene Expression Using Luciferase Bioluminescence Reporters
10:38

Monitoring Cell-autonomous Circadian Clock Rhythms of Gene Expression Using Luciferase Bioluminescence Reporters

Published on: September 27, 2012

Commentary: the year in circadian rhythms.

Paolo Sassone-Corsi1

  • 1Department of Pharmacology, University of California, Irvine, Irvine, California 92697-4625, USA. psc@uci.edu

Molecular Endocrinology (Baltimore, Md.)
|October 8, 2010
PubMed
Summary
This summary is machine-generated.

The circadian clock regulates physiological processes and metabolic programs. Recent research links circadian rhythms to endocrine control, cell cycle, and epigenetic mechanisms, offering new therapeutic avenues.

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Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures
06:53

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures

Published on: November 11, 2016

Related Experiment Videos

Last Updated: Jun 8, 2026

Monitoring Cell-autonomous Circadian Clock Rhythms of Gene Expression Using Luciferase Bioluminescence Reporters
10:38

Monitoring Cell-autonomous Circadian Clock Rhythms of Gene Expression Using Luciferase Bioluminescence Reporters

Published on: September 27, 2012

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures
06:53

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures

Published on: November 11, 2016

Area of Science:

  • Chronobiology
  • Endocrinology
  • Epigenetics

Background:

  • The circadian clock is a fundamental biological timing mechanism.
  • It governs diverse physiological and metabolic functions across organisms.
  • Recent advancements highlight its connection to disease and potential therapeutic targets.

Purpose of the Study:

  • To review recent spectacular developments in the field of circadian rhythms.
  • To highlight the link between circadian regulation and endocrine/metabolic control.
  • To underscore the role of circadian gene expression in chromatin remodeling and epigenetic control.

Main Methods:

  • Review of recent scientific literature and presentations.
  • Analysis of molecular pathways involved in circadian regulation.
  • Examination of the relationship between circadian rhythms, metabolism, and epigenetics.

Main Results:

  • Significant increase in research interest and resources dedicated to circadian rhythms.
  • Identification of specific molecular pathways linking circadian regulation to endocrine and metabolic control.
  • Circadian gene expression involves a substantial portion of cellular genes, implicating chromatin remodeling.

Conclusions:

  • The circadian machinery acts as a molecular interface between cellular metabolism and epigenetic control.
  • Emerging research promises novel pharmacological strategies targeting circadian pathways.
  • Circadian rhythms play a crucial role in maintaining physiological homeostasis and cellular regulation.