Distinguishing Ménétrier's disease from its mimics

Area of Science:

• Gastroenterology
• Pathology

Background:

• Ménétrier's disease (MD) is a rare hypertrophic gastropathy.
• Diagnosis can be challenging due to overlapping symptoms with other conditions.

Purpose of the Study:

• To establish firm diagnostic criteria for MD.
• To differentiate MD from its mimics using clinicopathological features.

Main Methods:

• Evaluated 48 patients referred for MD treatment.
• Assessed clinical presentation, lab values, and histopathology.

Main Results:

• MD confirmed in 52% of patients; mimics diagnosed in 48%.
• Histological findings in MD include foveolar hyperplasia, glandular changes, and reduced parietal cells.
• MD patients presented with younger age, male predominance, and more vomiting.

Conclusions:

• Clinicohistopathological analysis is key for accurate MD diagnosis.
• Recommended diagnostic tools include endoscopy, pH monitoring, lab tests, and biopsy.