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Related Concept Videos

Preclinical Development: Overview01:28

Preclinical Development: Overview

Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...
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Cooperative allosteric transitions can occur in multimeric proteins, where each subunit of the protein has its own ligand-binding site. When a ligand binds to any of these subunits, it triggers a conformational change that affects the binding sites in the other subunits; this can change the affinity of the other sites for their respective ligands. The ability of the protein to change the shape of its binding site is attributed to the presence of a mix of flexible and stable segments in the...
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Cooperative allosteric transitions can occur in multimeric proteins, where each subunit of the protein has its own ligand-binding site. When a ligand binds to any of these subunits, it triggers a conformational change that affects the binding sites in the other subunits; this can change the affinity of the other sites for their respective ligands. The ability of the protein to change the shape of its binding site is attributed to the presence of a mix of flexible and stable segments in the...
Cooperative Allosteric Transitions01:58

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Microbial cooperation involves beneficial interactions in which different species work together for individual or mutual advantage. These interactions can profoundly influence ecological dynamics and evolutionary processes, and they are essential to many pathogenic and symbiotic relationships.Nematode–Bacteria CooperationA striking example is the relationship between the Gram-negative bacterium Xenorhabdus nematophila and the parasitic nematode Steinernema carpocapsae. Juvenile nematodes...
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Related Experiment Video

Updated: Jun 8, 2026

Operation of the Collaborative Composite Manufacturing (CCM) System
10:09

Operation of the Collaborative Composite Manufacturing (CCM) System

Published on: October 1, 2019

Opening up to precompetitive collaboration.

Jill S Altshuler1, Erin Balogh, Anna D Barker

  • 1AltshulerGray, 61 Dean Road, Brookline, MA 02445, USA.

Science Translational Medicine
|October 8, 2010
PubMed
Summary
This summary is machine-generated.

Nontraditional research collaborations enhance biomedical innovation through shared information and resources. These precompetitive collaborations, common in oncology, offer valuable lessons for translational medicine research.

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Area of Science:

  • Biomedical Research
  • Translational Medicine
  • Oncology

Background:

  • Nontraditional research collaborations are emerging to boost biomedical R&D.
  • These collaborations involve sharing information, resources, and capabilities.
  • Many such initiatives are currently focused on oncology.

Purpose of the Study:

  • To highlight the emergence and benefits of nontraditional research collaborations.
  • To demonstrate the broad applicability of lessons learned from oncology collaborations.
  • To promote innovation in biomedical research and development.

Main Methods:

  • Analysis of emerging trends in biomedical research collaborations.
  • Review of information, resource, and capability sharing models.
  • Case study insights from precompetitive oncology collaborations.

Main Results:

  • Nontraditional collaborations significantly enhance R&D efficiency and innovation.
  • Precompetitive models in oncology provide transferable strategies.
  • Cross-disciplinary collaboration accelerates translational medicine.

Conclusions:

  • Precompetitive collaborations are a powerful model for advancing biomedical research.
  • Lessons from oncology can be effectively applied to other translational medicine fields.
  • Fostering collaboration is key to future biomedical innovation.