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Related Experiment Video

Updated: Jun 8, 2026

Individualized rTMS Treatment for Depression using an fMRI-Based Targeting Method

Individualized rTMS Treatment for Depression using an fMRI-Based Targeting Method

Published on: August 2, 2021

How rapidly should remission be achieved?

¹Division of Gastroenterology and Hepatology, University of North Carolina, Chapel Hill, NC 27599-7032, USA. klisaacs@med.unc.edu

Digestive Diseases (Basel, Switzerland)

|October 8, 2010

Summary

This summary is machine-generated.

Achieving remission in inflammatory bowel disease (IBD) involves clinical and endoscopic healing. Different therapies offer varying timelines for remission, impacting patient quality of life and disease course.

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Area of Science:

Gastroenterology
Immunology
Pharmacology

Background:

Inflammatory bowel disease (IBD) treatment aims to induce remission, defined by symptom resolution (clinical remission) and mucosal healing (endoscopic remission).
Mucosal healing is a critical but challenging therapeutic endpoint in IBD management.
Current clinical trials often rely on activity indices that may not fully capture the endoscopic and histologic status of the bowel.

Purpose of the Study:

To discuss the induction of clinical remission and mucosal healing in Crohn's disease and ulcerative colitis.
To review the impact of achieving early remission on the overall disease course in IBD patients.

Main Methods:

Review of therapeutic approaches for inducing remission in IBD.
Analysis of time to remission for various treatments including steroids, anti-TNF agents, mesalamine, azathioprine, and 6-mercaptopurine.
Discussion of clinical remission and endoscopic healing as treatment goals.

Main Results:

Steroids demonstrate rapid clinical effects, with remission observed in some patients within two weeks.
Early anti-TNF trials show significantly higher remission rates at two weeks compared to placebo.
Mesalamine shows variable remission rates in Crohn's disease but more consistent response in ulcerative colitis; immunomodulators have delayed onset but can induce remission with optimized dosing.

Conclusions:

The timing of remission induction varies significantly across different IBD therapies.
Early achievement of clinical and endoscopic remission is crucial for improving patient quality of life and potentially altering the long-term disease trajectory.
Understanding these temporal differences is key for optimizing IBD treatment strategies.