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Mitomycin C in patients with gynecological malignancies
Laura Kahmann1, Ulrich Beyer, Grit Mehlhorn
1University Breast Center for Franconia, Department of Gynecology, Erlangen University Hospital, Erlangen, Erlangen, Germany.
Abstract:
Mitomycin C (MMC) is an effective cytostatic agent used in the treatment of patients with gynecological malignancies and breast carcinoma. This review presents and discusses the current treatment options with MMC in patients with breast, cervical, and vulvar carcinomas, as well as rarer gynecological malignancies. New combinations and developments are also presented and their potential clinical relevance is examined. Consequently, also for the next years a MMC-containing chemotherapy continues to be a relevant part of an individualized therapy despite numerous innovative new drugs, especially for the salvage therapy of metastatic breast cancer and the simultaneous radiochemotherapy of other gynecological malignancies.
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