Related Experiment Video
Updated: Jun 8, 2026
07:14
Murine Model of Advanced Periodontitis Induced by Nylon Ligature in the Second Upper Molar
Published on: May 30, 2025
Bidirectional relationship between chronic kidney and periodontal disease: a study using structural equation
Monica A Fisher1, George W Taylor, Brady T West
1Department of Preventive Medicine and Public Health, University of Kansas School of Medicine, Wichita, Kansas 67214-3199, USA. mfisher2@kumc.edu
Kidney International
|October 8, 2010
Summary
Periodontal disease and chronic kidney disease (CKD) are linked. This study found a two-way relationship between these conditions, influenced by hypertension and diabetes duration.
Area of Science:
- Nephrology
- Periodontology
- Epidemiology
Background:
- Periodontal disease is linked to systemic conditions like diabetes and heart disease, potentially via vascular inflammation.
- A bidirectional link between chronic kidney disease (CKD) and periodontal disease is biologically plausible but previously unreported.
Purpose of the Study:
- To investigate the association between CKD and periodontal disease.
- To identify mediators in the CKD-periodontal disease relationship.
- To explore the potential bidirectional nature of this association.
Main Methods:
- Utilized data from 11,211 adults from the Third National Health and Nutrition Examination Survey.
- Employed multivariable logistic regression and structural equation models.
- Tested for mediation and examined direct/indirect effects between CKD and periodontal disease.
Main Results:
- Periodontal disease (aOR 1.62), edentulism (aOR 1.83), and periodontal disease score were independently associated with CKD.
- Three of four structural equation models supported the hypothesized bidirectional relationship.
- Hypertension and duration of diabetes were identified as significant mediators.
Conclusions:
- A bidirectional relationship exists between periodontal disease and CKD.
- Hypertension and diabetes duration mediate the link between these conditions.
- Findings suggest a complex interplay requiring further investigation.
Related Concept Videos
01:25Chronic Kidney Disease I: Introduction
Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
01:28Chronic Kidney Disease III: Interprofessional Care
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
01:24Chronic Kidney Disease II: Clinical Manifestations
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
01:18Chronic Kidney Disease IV: Nursing Management
Nursing management is essential for preventing complications, maintaining stability, and improving patients' quality of life in chronic kidney disease (CKD). By using a structured approach, nurses help slow CKD progression and support effective patient care.1. Comprehensive patient assessmentEffective management begins with nurses reviewing the patient’s medical history, and identifying key risk factors like diabetes, hypertension, and nephrotoxic drug use. Nurses assess signs of fluid...
01:27The Oral Microbiota
The oral microbiome includes a complex ecosystem comprising over 700 microbial species, identified through genomic sequencing and culture-based analyses to date. This community includes a core microbiome, found universally among individuals, and a variable component influenced by environmental factors such as diet, lifestyle, and host genetics. Site-specific conditions, including oxygen gradients, pH levels, and nutrient availability, determine the spatial distribution of these microorganisms...
01:15Teeth
The formation of teeth, also known as odontogenesis, is a complex process that begins in utero, around the sixth week of embryonic development. There are three stages to this process: the bud stage, the cap stage, and the bell stage.
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin and...
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin and...