Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Carbon monoxide and lethal arrhythmias.

J P Farber1, P J Schwartz, E Vanoli

  • 1Department of Physiology and Biophysics, University of Oklahoma Health Sciences Center, Oklahoma City 73190.

Research Report (Health Effects Institute)
|December 1, 1990
PubMed
Summary

Acute carbon monoxide exposure rarely causes ventricular arrhythmias in dogs with prior heart attacks. However, it can increase heart rate, potentially impacting patients with coronary artery disease.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Optimizing Peri-Operative Pain Management in Children With Long QT Syndrome and Catecholaminergic Polymorphic Ventricular Tachycardia Undergoing Left Cardiac Sympathetic Denervation: A Case Series on Continuous Erector Spinae Plane Block and Serratus Plane Block.

Paediatric anaesthesia·2025
Same author

The role of spatial distance in SARS-CoV-2 nosocomial transmission.

The Journal of hospital infection·2025
Same author

A Convolutional-Transformer Model for FFR and iFR Assessment From Coronary Angiography.

IEEE transactions on medical imaging·2024
Same author

The importance of rational chlorhexidine use.

British dental journal·2024
Same author

Effectiveness of SplashGuard Caregiver prototype in reducing the risk of aerosol transmission in intensive care unit rooms of SARS-CoV-2 patients: a prospective and simulation study.

The Journal of hospital infection·2023
Same author

Augmented reality is a new learning experience to strengthen infection prevention and control action.

The Journal of hospital infection·2023

Area of Science:

  • Cardiovascular Science
  • Toxicology
  • Animal Models

Background:

  • Sudden cardiac death animal models are crucial for studying fatal arrhythmias.
  • Myocardial infarction survivors are at risk for subsequent life-threatening arrhythmias.
  • Carbon monoxide (CO) is a common environmental toxin with known cardiovascular effects.

Purpose of the Study:

  • To investigate the arrhythmogenic potential of acute carbon monoxide exposure.
  • To assess the impact of CO on ventricular arrhythmias in a canine model of sudden cardiac death.
  • To evaluate CO's effects on heart rate and autonomic reflexes in susceptible and resistant dogs.

Main Methods:

  • Utilized a validated canine model of healed anterior myocardial infarction.
  • Induce ventricular fibrillation using exercise and acute myocardial ischemia.

Related Experiment Videos

  • Exposed 'susceptible' (prone to fibrillation) and 'resistant' (survive without fibrillation) dogs to varying carboxyhemoglobin levels (5-15%).

    • Main Results:

    • A trend toward increased heart rate was observed at all CO levels, significant at 15% carboxyhemoglobin.
    • In resistant dogs, CO augmented the bradycardic response to ischemia, possibly via enhanced neural reflexes.
    • CO worsened arrhythmias in a minority of cases, but this effect was not reproducible.

    Conclusions:

    • Acute carbon monoxide exposure is seldom directly arrhythmogenic in this canine model of healed myocardial infarction.
    • CO exposure increases heart rate, which may have clinical relevance for patients with coronary artery disease.
    • The study highlights potential autonomic and cardiac electrophysiology alterations induced by CO in compromised hearts.