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Updated: Jun 8, 2026

Technique of Conjunctival Biopsy and Direct Immunofluorescence for Diagnosing Mucous Membrane Pemphigoid
05:05

Technique of Conjunctival Biopsy and Direct Immunofluorescence for Diagnosing Mucous Membrane Pemphigoid

Published on: June 17, 2025

Kikuchi-fujimoto disease from eastern India.

Pankaj Singhania1, Rudrajit Paul, S Maitra

  • 1Department of Medicine, Medical College and Hospitals, Kolkata, India.

Journal of Global Infectious Diseases
|October 8, 2010
PubMed
Summary

Kikuchi

Area of Science:

  • Internal Medicine
  • Pathology
  • Rheumatology

Background:

  • Kikuchi's disease, also known as Kikuchi-Fujimoto disease, is a rare, self-limiting disorder.
  • It typically presents with fever, painful lymphadenopathy, rash, and arthritis, mimicking infectious and immunological conditions.
  • Diagnosis relies on histopathological examination, necessitating the exclusion of other connective tissue disorders and infections.

Observation:

  • This report details two cases of Kikuchi-Fujimoto disease.
  • Both cases primarily exhibited lymphadenopathy and fever.
  • One case presented with generalized lymphadenopathy, while the second involved a rare association with Systemic Lupus Erythematosus (SLE).

Findings:

  • Lymph node excision biopsy and subsequent histopathology confirmed Kikuchi-Fujimoto disease in both patients.
Keywords:
ArthritisHistiocytic necrotising lymphadenitisSystemic lupus erythematosus (SLE)

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Last Updated: Jun 8, 2026

Technique of Conjunctival Biopsy and Direct Immunofluorescence for Diagnosing Mucous Membrane Pemphigoid
05:05

Technique of Conjunctival Biopsy and Direct Immunofluorescence for Diagnosing Mucous Membrane Pemphigoid

Published on: June 17, 2025

  • The diagnostic process involved ruling out other potential etiologies.
  • Histopathological findings were crucial for definitive diagnosis.

    • Implications:

    • Kikuchi's disease requires a high index of suspicion due to its mimicry of other disorders.
    • Histopathological diagnosis is essential for accurate identification.
    • Early diagnosis and management lead to favorable outcomes with no residual stigmata.