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Updated: Jun 8, 2026

The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation
Published on: February 28, 2012
[Persistent left atrial thrombus in atrial fibrillation under oral anticoagulation]
B Leithäuser1, F Kasch, T Broemel
1Medizische Abteilung, Kardiologie/Angiologie, Asklepios Klinik Harburg, Eißendorfer Pferdeweg 52, 21075, Hamburg. b.leithaeuser@asklepios.com
Insights
This case highlights the challenges in preventing blood clots in patients with atrial fibrillation, even with adequate anticoagulation. It emphasizes the need for careful risk assessment using clinical and echocardiographic data.
Area of Science:
- Cardiology
- Thrombosis Research
Background:
- Atrial fibrillation poses a significant risk for thromboembolic events.
- Effective anticoagulation is crucial for stroke prevention in these patients.
Observation:
- A 78-year-old female with atrial fibrillation presented with a persistent left atrial appendage thrombus despite therapeutic anticoagulation.
- This case underscores the complexities in thromboembolism prophylaxis and risk stratification.
Findings:
- Clinical and echocardiographic criteria are vital for evaluating thromboembolic risk.
- Transesophageal echocardiography remains the gold standard for detecting intracardiac thrombi before cardioversion.
- Cardiac computed tomography offers a viable alternative for thrombus detection.
Implications:
- Accurate risk assessment is paramount for tailoring anticoagulation strategies.
- Advanced imaging modalities like transesophageal echocardiography and cardiac CT are essential for guiding treatment decisions.
- Further research may be needed to optimize anticoagulation protocols for high-risk atrial fibrillation patients.
Abstract:
The case of a 78-year-old female patient who suffered atrial fibrillation and persistent thrombus in the left atrial appendage despite sufficient anticoagulation is reported. The case is chosen to demonstrate the complexity inherent in prophylaxis as well as risk evaluation of thromboembolism on the basis of clinical and echocardiographic criteria. We also discuss transesophageal echocardiography as the standard diagnostic procedure for detection of intracardiac thrombi prior to cardioversion as well as cardiac computer tomography as an alternative.
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