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Updated: Jun 8, 2026
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Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
Published on: January 18, 2018
Percutaneous vascular interventions for acute ischaemic stroke.
Killian O'Rourke1, Eivind Berge, Cathal D Walsh
1Dublin Neurological Institute, Mater University Hospital, 57 Eccles Street, Dublin 7, Ireland.
The Cochrane Database of Systematic Reviews
|October 8, 2010
Summary
Percutaneous vascular interventions for acute ischemic stroke improve patient outcomes but increase the risk of brain bleeding. Further research is needed to confirm these findings and assess cost-effectiveness.
Area of Science:
- Neurology
- Interventional Cardiology
- Vascular Surgery
Background:
- Large artery blockages cause most disabling strokes.
- Prompt clot removal via percutaneous vascular interventions can improve recovery.
- These interventions carry a risk of intracranial hemorrhage.
Purpose of the Study:
- To evaluate the safety and efficacy of percutaneous vascular interventions for acute ischemic stroke.
Main Methods:
- Systematic review of randomized controlled trials.
- Searched multiple databases (Cochrane, MEDLINE, EMBASE) and trial registers.
- Included trials comparing percutaneous interventions with control in ischemic stroke patients.
Main Results:
- Four trials with 350 patients were included.
- Interventions up to 6 hours post-stroke improved favorable outcomes (modified Rankin 0-2) at 3 months (RR 1.47).
- Symptomatic intracranial hemorrhage risk increased (RR 3.85), but heterogeneity was not significant.
Conclusions:
- Percutaneous interventions improve outcomes but increase intracranial hemorrhage risk.
- Further trials are necessary to confirm efficacy and assess feasibility and cost-effectiveness.
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