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Updated: Jun 8, 2026

Utility of Dissociated Intrinsic Hand Muscle Atrophy in the Diagnosis of Amyotrophic Lateral Sclerosis
Published on: March 4, 2014
Experience with the Awaji Island modifications to the ALS diagnostic criteria
Amy Chen1, Louis Weimer, Thomas Brannagan
1Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York, USA. amy_chen@urmc.rochester.edu
Abstract:
Amyotrophic lateral sclerosis (ALS) remains a clinical diagnosis without validated biomarkers. To increase diagnostic sensitivity, an expert group modified the Airlie House diagnostic criteria and formulated new recommendations at a meeting on Awaji Island. Our retrospective analysis of patients referred over a 6-month period to the electromyography (EMG) laboratory for suspected motor neuron disease (MND) showed a higher agreement of the Awaji modifications than the Airlie House criteria with the clinical diagnosis of ALS.
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