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[Immunobiologic properties of lactobacilli]
V Mihál1, V Lackovic, M Plocková
1Katedra pediatrie Lekárskej fakulty Univerzity Palackého, Olomouc.
Ceskoslovenska Pediatrie
|October 1, 1990
Summary
Selected lactobacilli strains, Lactobacillus acidophilus and Lactobacillus casei, enhance immune responses in mice. Oral or intraperitoneal administration improved lymphocyte migration and survival against viral infections, with some strains boosting interferon production.
Area of Science:
- Immunology
- Microbiology
- Gastroenterology
Context:
- Lactobacilli are known for their probiotic effects.
- Understanding their immunomodulatory mechanisms is crucial for therapeutic applications.
- Gut microbiota plays a significant role in host immunity.
Purpose:
- To investigate the immunobiological properties of specific Lactobacillus strains (acidophilus, casei, delbruecki) in mice.
- To evaluate the immunostimulating effects on gut immune cells and protective capacity against viral infections.
- To assess the influence of these lactobacilli on interferon production.
Summary:
- Administration of Lactobacillus acidophilus and Lactobacillus casei via gastric tube increased lymphocyte migration into the gut's interepithelial spaces and lamina propria.
- Intraperitoneal administration of L. casei and L. acidophilus four days before encephalomyocarditis virus infection significantly improved survival rates (66% and 34%, respectively).
- While lactobacilli alone did not induce interferon, they enhanced the interferon-producing capacity of peritoneal cells when stimulated with Newcastle disease virus.
Impact:
- Demonstrates the potential of specific Lactobacillus strains as immunomodulators.
- Highlights the efficacy of L. acidophilus and L. casei in enhancing host defense against viral pathogens.
- Suggests a synergistic effect between lactobacilli and viral inducers on interferon production, relevant for vaccine development or antiviral strategies.