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pH-Sensitive breathing of clay within the polyelectrolyte matrix
Piyush Chaturbedy1, Dinesh Jagadeesan, Muthusamy Eswaramoorthy
1Nanomaterials and Catalysis Lab, Chemistry and Physics of Materials Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore-560064, India.
ACS Nano
|October 9, 2010
Summary
Synthesized hybrid spheres change size with pH. This pH-responsive swelling was used to control the release of drugs like ibuprofen.
Area of Science:
- Materials Science
- Nanotechnology
- Polymer Chemistry
Background:
- Stimuli-responsive materials offer controlled release applications.
- Organic-inorganic hybrid materials combine properties of both components.
- Layer-by-layer assembly is a versatile technique for creating structured coatings.
Purpose of the Study:
- To synthesize stimuli-responsive hybrid spheres.
- To investigate the pH-dependent swelling behavior of these spheres.
- To demonstrate controlled drug release using these spheres.
Main Methods:
- Layer-by-layer assembly of polyelectrolyte and aminoclay (Mg phyllo(organo)silicate) on polystyrene spheres.
- pH-triggered swelling of aminoclay due to protonation of amino groups.
- Monitoring sphere size changes across a pH range (9 to 4).
- Utilizing the size-change property for controlled release of ibuprofen and eosin.
Main Results:
- Successfully synthesized hybrid spheres with tunable size.
- Observed significant sphere size changes (up to 60%) with varying pH.
- Demonstrated pH-controlled release of model drugs (ibuprofen and eosin).
Conclusions:
- The synthesized hybrid spheres exhibit significant pH-responsive behavior.
- This pH-sensitivity enables controlled release of active compounds.
- The developed material holds potential for advanced drug delivery systems.
