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Related Concept Videos

Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...
Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...
Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response01:15

Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response

Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
Biological Clocks and Seasonal Responses02:45

Biological Clocks and Seasonal Responses

The circadian—or biological—clock is an intrinsic, timekeeping, molecular mechanism that allows plants to coordinate physiological activities over 24-hour cycles called circadian rhythms. Photoperiodism is a collective term for the biological responses of plants to variations in the relative lengths of dark and light periods. The period of light-exposure is called the photoperiod.
Factors Affecting Drug Biotransformation: Biological01:19

Factors Affecting Drug Biotransformation: Biological

Biological factors significantly impact drug metabolism, influencing drug clearance, efficacy, and potential toxicity.
Species differences: Variations in enzyme systems across species can cause disparities in drug metabolism. For instance, humans may metabolize certain drugs faster than rodents, altering therapeutic effects.
Strain differences: Genetic variations within a species can result in differing enzyme activity, impacting drug response and toxicity. For example, some mouse strains may...
Regulation of Metabolism01:19

Regulation of Metabolism

Cellular needs and conditions vary from cell to cell and change within individual cells over time. For example, the required enzymes and energetic demands of stomach cells are different from those of fat storage cells, skin cells, blood cells, and nerve cells. Furthermore, a digestive cell works much harder to process and break down nutrients during the time that closely follows a meal compared with many hours after a meal. As these cellular demands and conditions vary, so do the amounts and...

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Updated: Jun 8, 2026

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures
06:53

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures

Published on: November 11, 2016

The circadian clock and metabolism.

Oren Froy1

  • 1Institute of Biochemistry, Food Science and Nutrition, Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot, Israel. froy@agri.huji.ac.il

Clinical Science (London, England : 1979)
|October 9, 2010
PubMed
Summary

Mammals possess a central circadian clock in the brain that synchronizes with light-dark cycles. This internal clock influences metabolism, and disruptions in circadian rhythm genes impact metabolic homeostasis.

Area of Science:

  • Chronobiology
  • Metabolic Regulation
  • Physiology

Background:

  • Mammals have an internal biological clock, the suprachiasmatic nuclei (SCN), synchronized by environmental light.
  • This circadian clock regulates physiological functions and metabolic processes in both central and peripheral tissues.
  • Disruptions in circadian rhythmicity are linked to metabolic homeostasis imbalances.

Purpose of the Study:

  • To review recent findings on the intricate relationship between circadian rhythms and metabolism.
  • To highlight how the circadian clock influences cellular and physiological functions, including metabolic pathways.
  • To explore the bidirectional interaction between metabolic regulators and the core clock mechanism.

Main Methods:

  • Literature review of recent scientific findings.

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In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells
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Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures
06:53

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures

Published on: November 11, 2016

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In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells

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  • Analysis of studies on circadian clock genes and their effect on metabolic homeostasis.
  • Examination of research on the interaction between metabolic enzymes and the core clock.

    • Main Results:

    • The circadian clock regulates key metabolic enzymes and hormones.
    • Metabolic enzymes and transcription factors interact with and influence the core circadian clock.
    • Mutations in clock genes disrupt cellular rhythmicity and affect metabolic homeostasis.

    Conclusions:

    • A strong link exists between the circadian clock system and metabolic regulation.
    • Understanding this relationship is crucial for addressing metabolic disorders.
    • Further research into circadian biology and metabolism is warranted.