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Updated: Jun 8, 2026

In Vitro Differentiation Model of Human Normal Memory B Cells to Long-lived Plasma Cells
Published on: January 20, 2019
Epigenetic modifications as key regulators of Waldenstrom's Macroglobulinemia biology
Antonio Sacco1, Ghayas C Issa, Yong Zhang
1Dana-Farber Cancer Institute, Medical Oncology, Harvard Medical School, Boston, MA, USA. aldo_roccaro@dfci.harvard.edu
Abstract:
Waldenstrom's Macroglobulinemia is a low-grade B-cell lymphoma characterized by the presence of lymphoplasmacytic cells in the bone marrow and a monoclonal immunoglobulin M in the circulation. Recent evidences support the hypothesis that epigenetic modifications lead to Waldesntrom cell proliferation and therefore play a crucial role in the pathogenesis of this disease. Indeed, while cytogenetic and gene expression analysis have demonstrated minimal changes; microRNA aberrations and modification in the histone acetylation status of primary Waldenstrom Macroglobulinemia tumor cells have been described. These findings provide a better understanding of the underlying molecular changes that lead to the initiation and progression of this disease.
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