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Asthma: Pathogenesis and Management

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Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
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Related Experiment Video

Updated: Jun 8, 2026

Immunofluorescent Labeling in Nasal Mucosa Tissue Sections of Allergic Rhinitis Rats via Multicolor Immunoassay

Immunofluorescent Labeling in Nasal Mucosa Tissue Sections of Allergic Rhinitis Rats via Multicolor Immunoassay

Published on: September 22, 2023

Allergic rhinitis: Pathophysiology.

David H Broide¹

¹Department of Medicine, University of California San Diego, 92093-0635, USA. dbroide@ucsd.edu

Allergy and Asthma Proceedings

|October 9, 2010

Summary

Allergic rhinitis involves immediate and late-phase inflammatory responses. Recent research highlights new pathways, including local immunoglobulin E (IgE) synthesis and epithelial-derived cytokines, offering potential new therapeutic targets.

Area of Science:

Immunology
Allergology
Otorhinolaryngology

Background:

Allergic rhinitis involves complex inflammatory cascades in the nasal mucosa.
Immediate responses are IgE-mediated, while late-phase responses involve eosinophils, basophils, and T cells.

Purpose of the Study:

To review established pathways in allergic rhinitis pathophysiology.
To update knowledge on recent advances and novel contributing factors.

Main Methods:

Literature review of original articles from PubMed.
Focus on in vitro, in vivo, and preclinical studies.

Main Results:

Local IgE synthesis in nasal mucosa is possible.
Epithelial cytokines (TSLP, IL-25, IL-33) regulate Th2 responses.

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Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy

Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy

Published on: April 16, 2019

Related Experiment Videos

Last Updated: Jun 8, 2026

Immunofluorescent Labeling in Nasal Mucosa Tissue Sections of Allergic Rhinitis Rats via Multicolor Immunoassay

Immunofluorescent Labeling in Nasal Mucosa Tissue Sections of Allergic Rhinitis Rats via Multicolor Immunoassay

Published on: September 22, 2023

Absorption of Nasal and Bronchial Fluids: Precision Sampling of the Human Respiratory Mucosa and Laboratory Processing of Samples

Absorption of Nasal and Bronchial Fluids: Precision Sampling of the Human Respiratory Mucosa and Laboratory Processing of Samples

Published on: January 21, 2018

Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy

Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy

Published on: April 16, 2019

H₄-histamine receptors mediate itching; regulatory T cells may induce tolerance.

Conclusions:

Emerging pathways offer new insights into allergic rhinitis.
Understanding these mechanisms may reveal novel therapeutic targets.