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Updated: Jun 8, 2026
Quantitative Immunohistochemistry of the Cellular Microenvironment in Patient Glioblastoma Resections
Published on: July 31, 2017
[Survival pronostic factors in Mexican patients with multiforme glioblastoma]
Ricardo Hernández-Reyna1, Roberto Medellín-Sánchez, Ricardo M Cerda-Flores
1Departamento de Neurocirugía, Hospital de Especialidades 25, Instituto Mexicano del Seguro Social, Monterrey, Nuevo León, Mexico.
Objective:
To study the pre- and transoperative factors that influence patients' survival with GM.
Methods:
Clinical and pathological records of all confirmed cases of GM diagnosed between 2000 and 2006 were included. Postoperative survival was divided in less or more than 8 months. χ2 test was used.
Results:
One hundred and twenty patients (45 women and 75 men) were studied. Age range was from 7 to 85 years, 3.3% were 16 years old or younger and 12.5% were 70 years old or older. Headache was the most frequent complain, 40 patients developed hemiparesia and 6 had parestesias. Predominance of white matter hemispheric lesions was observed: right hemispheric tumors 65 (54%), left lesions 30 (25%) and bilateral tumors 7%. Histologically, 1.6% of GM had a sarcomatous component; 35% of patients survived less than 8 months. A difference between patients survival was the preoperative Karnofsky Performance Scale Score and the degree of cerebral edema during the surgical procedure.
Conclusions:
Pre-operative Karnofsky evaluation and edema during the surgical procedure were significant prognostic factors for survival.
