[Study on expression of disaccharide residue and its significance in lung cancer tissues.]
1CT Department , Hebei Province Chest Hospital , Shijiazhuang , 050041 , P. R. China.
Background:
To study the expression of disaccharide residu (D-Galactose-beta-(1v3)-N-Acetyl- galactosamine) in lung cancer.
Methods:
Surgical dissected samples from 109 cases of lung cancer and 87 cases of lung benign diseases were fixed in 4 % formaldehyde and embeded in parafin. Disaccharide residue was examined by galactose oxidase-Schiff's method.
Results:
The positive rate of bronchial submucous glands from patients with lung cancer was 71. 76 %(61/ 85) , and the positive rate of bronchial submucous gland from patients with benign pulmonary diseases was 71. 83 %(51/ 71) . There was no significant difference between two groups (Chi-Square = 0. 0026 , P > 0. 9) . Among 94 cases of lung cancer tissues , the positive rate of adenocarcinoma was 36. 11 %(13/ 36) , and the other lung cancer were negative reaction.
Conclusions:
The study showed that disaccharide residue was expressed in submucous glands of bronchial submuca in both patients with pulmonary benign or malignant diseases , and only expressed in partial adenocarcinoma tissues among the pulmonary carcinoma. It has not enough evidence to differentiate benign from malignant diseases of lung.