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[Determination of 5-FU in serumand tissues after nebulization in patients with lung cancer.]
1Thoracic Department of Jinan Area General Hospital of PLA , Jinan 250031 , P. R. China.
Background:
To observe the distribution of 5-FU in serum and respiratory system after nebulization in patients with lung cancer.
Methods:
Ten patients with lung cancer were given 40 ml of 1. 25 % 5-FU by nebulization twice every day. At the same time , other 10 patients with lung cancer , chosen as control group , were given 0. 75g of 5-FU intravenously once every day. The concentration of 5-FU in serum and respiratory systemwas determined by chromatography.
Results:
The highest concentration of serum 5-FU was (4. 59 +/-1. 77)mg/L in nebulization group and (10. 46 +/-1. 46)mg/L in control group respectively ( P < 0. 001) . Compared with the control group , the 5-FU concentration for nebulization group was remarkably higher in main bronchi ( P < 0. 05) . The 5-FU concentration in peripheral lung and hilar lymph nodes and tumor tissue had no significant difference for both groups ( P > 0. 05) .
Conclusions:
The 5-FU concentration was significantly higher in respiratory system and lower in serum by nebulization than by injection. Nebulization can lessen the toxic reaction and offer a safe and effective route for chemotherapy.
