Related Experiment Video
Updated: Jun 8, 2026

An Ex vivo Assay to Study Candida albicans Hyphal Morphogenesis in the Gastrointestinal Tract
Published on: July 1, 2020
Asc1, a WD-repeat protein, is required for hyphal development and virulence in Candida albicans
Xiaoyan Liu1, Xinyi Nie, Yufeng Ding
1Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, China.
Abstract:
Candida albicans is a human pathogenic fungus which can undergo a morphological transition from yeast to hyphae in response to a variety of environmental stimuli. We analyzed a C. albicans Asc1 (Absence of growth Suppressor of Cyp1) protein which is entirely composed of seven repeats of the WD domain, and is conserved from fungi to metazoan. Deleting the ASC1 in C. albicans led to a profound defect in hyphal development under hypha-inducing conditions examined. Furthermore, deletion of the ASC1 attenuated virulence of C. albicans in a mouse model of systemic infection. These data strongly suggested that the conserved WD-repeat protein Asc1 is required for morphogenesis and pathogenesis of C. albicans.
Related Concept Videos
Anaphase Promoting Complex
Candidiasis
Canonical Wnt Signaling Pathway
Regulation of Bacterial Virulence
Separation of Sister Chromatids
At the onset of anaphase, separase, a proteolytic enzyme, is...
Protein Complexes with Interchangeable Parts
The SCF ubiquitin ligase is a protein complex of five individual proteins. This complex attaches ubiquitin to other target proteins to mark them for degradation. In order to...

