Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Clinical development programme for omeprazole.

A Walan1

  • 1Department of Clinical Pharmacology and Medicine, AB Hässle, Mölndal, Sweden.

Digestion
|January 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Seven-year follow-up of a randomized clinical trial comparing proton-pump inhibition with surgical therapy for reflux oesophagitis.

The British journal of surgery·2007
Same author

Changes of gastric mucosal architecture during long-term omeprazole therapy: results of a randomized clinical trial.

Alimentary pharmacology & therapeutics·2006
Same author

Cure of Helicobacter pylori infection in patients with reflux oesophagitis treated with long term omeprazole reverses gastritis without exacerbation of reflux disease: results of a randomised controlled trial.

Gut·2003
Same author

Quality of life in chronic NSAID users: a comparison of the effect of omeprazole and misoprostol.

Scandinavian journal of rheumatology·2002
Same author

Changing patterns of Helicobacter pylori gastritis in long-standing acid suppression.

Helicobacter·2001
Same author

Long-term omeprazole treatment in resistant gastroesophageal reflux disease: efficacy, safety, and influence on gastric mucosa.

Gastroenterology·2000

Omeprazole offers faster relief and healing for ulcers and reflux esophagitis compared to H2-receptor antagonists. It demonstrates a good safety profile and efficacy in various ulcer treatments.

Area of Science:

  • Gastroenterology
  • Pharmacology

Background:

  • Omeprazole demonstrates superior efficacy over H2-receptor antagonists in treating duodenal ulcers, gastric ulcers, and reflux esophagitis.
  • It is well-tolerated with a favorable safety profile.

Purpose of the Study:

  • To evaluate the clinical development areas of omeprazole, including maintenance therapy for duodenal ulcers and reflux esophagitis.
  • To assess omeprazole's effectiveness in treating NSAID-induced gastro-duodenal lesions and bleeding ulcers.

Main Methods:

  • Comparative studies assessing omeprazole's efficacy against placebo and ranitidine for various gastrointestinal conditions.
  • Evaluation of maintenance treatment protocols and treatment of NSAID-induced ulcers and bleeding ulcers.

Main Results:

Related Experiment Videos

  • Omeprazole maintenance therapy for duodenal ulcers was effective at lower doses and superior to placebo.
  • Higher healing rates were observed for NSAID-induced gastric ulcers with omeprazole compared to ranitidine.
  • Omeprazole showed superior remission rates in reflux esophagitis and better bleeding control in bleeding peptic ulcers.

Conclusions:

  • Omeprazole is a highly effective treatment for duodenal ulcers, gastric ulcers, and reflux esophagitis, offering rapid symptom relief and reliable healing.
  • Its efficacy extends to maintenance therapy, NSAID-induced lesions, and bleeding ulcers, with a good safety profile.