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Published on: February 3, 2012
Cowden syndrome
S M Ravi Prakash1, G N Suma, Sumit Goel
1Department of Oral Medicine and Radiology, Kothiwal Dental College and Research Centre, Mora Mustaqueem, Moradabad (U.P.), India. sasan_ravi@rediffmail.com
Abstract:
Cowden syndrome or multiple hamartoma syndrome is an autosomal dominant condition with variable expressions that result mainly from mutation in the PTEN gene on arm 10q. It is characterized by multiple hamartomatous neoplasms of the skin, oral mucosa, gastrointestinal tract, bones, CNS, eyes, and genitourinary tract. Mucocutaneous features include trichilemmomas, oral mucosal papillomatosis, acral keratosis, and palmoplantar keratosis. Here we present a case of Cowden syndrome in a 14-year-old female patient with the chief complaint of multiple oral papillomatous lesions.
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